Why is sequence blindness acceptable with antibodies?

Date: 24 November 2021
Time: 3:00 pm

Website: bit.ly/3q0X3CY

More and more antibodies today are engineered in complex and innovative ways and then produced recombinantly from a known amino acid sequence. With recombinant expression, it is still vital to ensure that the end product, which is the protein produced by the expression system, indeed has the same exact sequence.

For protein sequence confirmation to be practical and routine in research, diagnostic or therapeutic work, a low-cost, fast and high-throughput solution is needed. This would lead to increased confidence and importantly, scientists can efficiently complement their validation efforts with protein sequence confirmation. The latter will allow them to significantly reduce the time and cost of traditionally exhaustive validation experiments so they can focus on the important work at hand. In this webinar, we discuss potential solutions for protein sequence confirmation to eliminate “sequence blindness”.

What you will learn:

• Why is the protein sequence integral to antibody reproducibility?
• How the protein sequence is at the core of antibody function
• Why are protein sequences not routinely part of validation?
• How is a protein sequence confirmed?
• Overview of the means through which protein sequences are traditionally confirmed or obtained
• How protein sequence confirmation can be incorporated into routine quality control.