Triggering ferroptosis in cancer cells

While it is well known that interferon gamma is involved in anti-tumour responses, the new study, published in Cancer Cell,¹ defines a novel way that this cytokine works. The researchers found that the combination of interferon gamma with arachidonic acid, a fatty acid found in the tumour microenvironment, activates the ACSL4 enzyme. This, in turn, alters tumour cell lipid patterns and naturally induces tumour cell ferroptosis via T cells.