Unique self-activating proteins for drug discovery

Published: 8 January 2024

Explore cutting-edge hit-to-lead insights through exclusive interviews and studies by leading experts in the field.

In this eBook, we explore how researchers identified two unique proteins within N. fowleri – self-activating guanine nucleotide-hydrolysing proteins (G proteins) – that present novel targets for drug discovery. This article summarises their work to date, including a high-throughput fluorescence assay of guanine nucleotide hydrolysis.

But that’s not all. From a database of more than 200,000 high-resolution, three-dimensional images of human induced pluripotent stem cells, researchers have devised a model to quantify cell shape and internal organisation. Susanne Rafelski, Deputy Director of the Allen Institute for Cell Science, revealed details of their study to Drug Target Review.

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Unique self-activating proteins for drug discovery

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