Understanding intracellular processes improves LYTACs therapy
New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.
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The power of combinations in blood cancers
Haematology research is a cradle of innovation, with many firsts in therapeutic approaches utilising the latest technology for the treatment of blood cancers. Anas Younes, Senior Vice President, Head of Haematology Oncology Research and Development at AstraZeneca, envisions a future where potential cures are within reach for more blood cancers…
Human organoid research offers insights into gut cell differentiation
How stem cells become enteroendocrine cells using gut organoids could have positive implications for many gastrointestinal diseases.
Alternate origin discovered for brain mosaicism and focal epilepsy
Researchers gain insight into how brain tissue is impacted differently by genetic problems compared to the rest of the body.
New molecular insights on medical cannabis
A study explores some key biological mechanisms that help explain the therapeutic effects of medicinal cannabis on inflammation and other disease states. Here, researchers from the European Molecular Biology Laboratory outline their investigations into the effect of tetrahydrocannabinol (THC) on the enzyme Autotaxin.
Cancer drug discovery: protein-ligand interactions
Dr Rob van Montfort, a leading researcher at the Centre for Cancer Drug Discovery (CCDD) within The Institute of Cancer Research, London, is at the forefront of cancer drug discovery. Focusing on protein-ligand interactions, his work utilises structural biology and biochemical methods to help the discovery of novel small-molecule drugs…
Women in Stem with Ashley Hall
"Throughout my education I was discouraged by many around me." - This October edition of our Women in Stem series spotlights Ashley Hall, Chief Development Officer of Reneo Pharmaceuticals. Ashley shares her experiences, challenges, and insights. Her STEM journey began with a fascination for science, leading her to overcome initial…
AI in gene delivery vector discovery and design
Dr Fernando Garces, Director of Biotechnology and Innovation at BioMap, discusses the huge potential of AI to deliver successful cell and gene therapy products by optimised design of viral vectors.
Protein offers promise for treatment of reproductive conditions
Scientists found that CXCR4 protein expression outside of the uterus is important for pregnancy maintenance.
Microbiotica: transforming medicine with microbiome magic
In this interview, Anne Neville, Director at Microbiotica, elaborates on the significance of the Microbiotica Culture Collection (MCC) and Microbiotica Reference Genome Database (MRGD), which are fundamental to the development of live biotherapeutic medicines.
Emotional scars: stigma with female adult acne
New research presented at the European Academy of Dermatology and Venereology (EADV) Congress 2023 in Berlin, Germany, has highlighted a previously underestimated aspect of acne's impact on individuals: its profound influence on social perception.
Could scratching nerve cells be the itch solution?
The sensation of itch is something everyone has experienced at some point in their lives. It's a natural response to various irritants, from insect bites to dry skin. But what happens when the urge to itch becomes relentless, causing discomfort and, in some cases, serious health problems?
Novel method for early cancer diagnosis
A recent scientific collaboration, led by the Institute of Nuclear Physics of the Polish Academy of Sciences, has overcome measurement challenges, enabling reliable cancer diagnosis.
Amino acid promotes tumour growth
Research into how the amino acid arginine drives metabolic reprogramming offers promise for liver cancer treatment.
Patient-derived organoids in disease modelling
In an exclusive interview with Nikki Carter at Molecular Devices, we explore the the power of patient-derived organoids (PDOs) in drug discovery.
