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Antibody pipelines – the pharma perspective

21 June 2022 | By Dr Erik Vernet (Novo Nordisk)

Dr Erik Vernet, Director of Antibody Technology at Novo Nordisk, discusses antibody discovery and development workflows, including the role of informatics processes, in this Q&A.

Providing new hope for rare disease using non-viral gene therapy

20 June 2022 | By Brent Warner (Poseida Therapeutics)

Viral vectors to deliver gene therapies are utilised by clinically approved therapies. However, this method is not the only option for advanced therapeutics. In this piece, Brent Warner, President, Gene Therapy at Poseida Therapeutics, discusses the balance between efficacy and safety in gene therapy, highlighting positive pre-clinical data for non-viral…

The promise of cell therapy: scaling up a new treatment paradigm for hearing loss

20 June 2022 | By Dr Terri Gaskell (Rinri Therapeutics)

Expectations are growing worldwide for discoveries that will harness the potential of cell therapy, which has already brought breakthroughs in therapeutic areas where there is an unmet need, from oncology to ophthalmology and rare disease. In this article, Dr Terri Gaskell, Chief Technology Officer at Rinri Therapeutics, explores some of…

Challenges and opportunities: lessons learned in developing potential gene therapy cures

17 June 2022 | By Dr Gaurav Shah (Rocket Pharmaceuticals)

While the full potential of gene therapies continues to be realised, their successes in rare diseases promote them as a promising treatment modality. Dr Gaurav Shah, Chief Executive Officer of Rocket Pharmaceuticals discusses the future of gene therapies as well as the company’s progress in in vivo and ex vivo programmes.

Leveraging a dual technology platform to develop gene therapies for a range of rare diseases

17 June 2022 | By Dr Mary Spellman (Castle Creek Biosciences Inc.)

In this article, Dr Mary Spellman, Chief Medical Officer and Senior Vice President of R&D at Castle Creek Biosciences, discusses how a versatile dual platform of ex vivo and in vivo gene therapy technologies is being utilised for the development of novel gene therapies for a broad range of rare…

Spatial biology is the next life science revolution

17 June 2022 | By Dr Richard Goodwin (AstraZeneca)

Dr Richard Goodwin, Head of Imaging & AI, Clinical Pharmacology & Safety Sciences at AstraZeneca, explores the latest innovation in early therapeutic development – spatial biology.

Drug Target Review Stem Cells ebook

16 June 2022 | By Drug Target Review

This ebook includes a piece by Daniel Morales- Mantilla, Dr Robin Parihar and Dr Katherine King, from Baylor College of Medicine, on a stem and progenitor cell infusion to improve the survival of mice from sepsis as well as an article by Dr Karen Litwa, East Carolina University, that explores…

Drug Target Review Imaging ebook

16 June 2022 | By Drug Target Review

In this section, Dr Peter O’Toole, University of York, examines innovation in the field of microscopy for drug discovery and development research, while in an exclusive Q&A, Dr Michael Grange, Rosalind Franklin Institute, discusses the advantages of utilising cryo-electron tomography imaging.

Drug Target Review Screening ebook

15 June 2022 | By Drug Target Review

This ebook features insights into the discovery of a new non-linear chiroptical effect for characterising nanohelices in miniscule volumes, and a novel organoid drug-screening platform with numerous eco benefits.

Drug Target Review Cell & Gene Therapy ebook

15 June 2022 | By Drug Target Review

This ebook features articles from gene therapy specialists that look at current platforms as well as the future of promising modalities for gene therapies. It also tackles novel stem cell technology considerations and gives insight into the careful balancing act between efficacy and safety in gene therapy.

Drug Target Review – Issue 2 2022

14 June 2022 | By Drug Target Review

In this issue are articles focusing on a novel stem cell therapy for hearing loss, how a non-linear chiroptical effect could aid drug discovery and the advantages of cryo-electron tomography for imaging research. Also included are pieces on gene therapy, spheroids and genomics.

COVID-19 Vaccine injection vector illustration. A doctor injects a coronavirus vaccine to a patient on green background

The legacy of COVID in vaccine research

16 May 2022 | By Dr Owen Seddon (University Hospital of Wales)

Dr Owen Seddon, University Hospital of Wales, looks at how lessons learned during the pandemic can inform pre-clinical and early R&D phases of future vaccine work.

Genome map/genomic studies illustration on blue background

Closing the diversity gap in genomics

5 May 2022 | By Ria Kakkad (Drug Target Review)

In this article, Drug Target Review’s Ria Kakkad explores the importance of diverse and inclusive samples in genomic studies with Assistant Professor Lindsay Fernández-Rhodes, Pennsylvania State University.

Cell with Pipette and Needle injecting Biological Material - 3d Illustration

Cell line development tactics and strategies for faster Investigational New Drug timelines

26 April 2022 | By Soojin Han (Samsung Biologics America)

Complexities related to the development of stable cell lines and increased risk of contamination in upstream and downstream processes, have led many developers to seek critically needed expertise from external partners. Soojin Han, Samsung Biologics America, offers an expert look at the various challenges and tactics that can be applied.

Key takeaways from the AACR Meeting 2022

19 April 2022 | By Victoria Rees (Drug Target Review)

Drug Target Review's Editor Victoria Rees brings you the highlights from the American Association for Cancer Research Meeting 2022.

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