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Researchers investigate gene network to identify “cancer driver genes”
The new study looked at the network of gene-gene interactions associated with cancer onset and progression to identify therapeutic targets.
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acute myeloid leukaemia
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Removal of RNA-binding protein improves leukaemia survival
Study shows that removing the protein IGF2BP3 slows cancer growth and increases chances of survival of rare types of leukaemia in mice.
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Open innovation – a collaboration between academia and the pharmaceutical industry to further leverage drug discovery expertise and assets
Increasing numbers of companies in the pharma industry are consolidating their services and outsourcing to CROs to reduce business costs. AstraZeneca’s Marian Preston, David Murray and Mark Wigglesworth discuss how this can not only drive innovation but also prove successful in identifying lead compounds, as evidenced through recent collaborations.
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Leukaemia protective role of Y chromosome gene discovered
Scientists have discovered the first leukaemia protective gene that is specific to the male-only Y chromosome...
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Inhibiting METTL3 destroys AML cells without harming normal blood cells
An unexpected drug target for acute myeloid leukaemia could open new avenues to develop effective treatments against the potentially lethal disease...
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BTSA1 causes cancer to self-destruct without affecting healthy cells
Scientists have discovered a compound that causes cancer cells to self-destruct while sparing healthy cells...
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Breakthrough in better understanding of acute myeloid leukaemia
A study led by the University of Birmingham has made a breakthrough in the understanding of how different genetic mutations cause acute myeloid leukaemia.
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Vulnerabilities of leukaemia cells revealed using CRISPR genome editing technique
18 October 2016 | By Niamh Louise Marriott, Digital Content Producer
Researchers from the Wellcome Trust have adapted a CRISPR gene editing technique and used it to find new therapeutic targets for acute myeloid leukaemia...