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3D map reveals DNA organisation within human retina cells
Scientists shed light on how genetic architecture in human retina cells determine gene expression, tissue-specific function, and disease phenotype in blinding diseases.
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age-related macular degeneration (AMD)
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Retinal cell map could advance precise cell and gene therapies for retinal diseases
Researchers have identified distinct differences among the cells comprising a tissue in the retina, findings that could help develop precise therapies for retinal diseases.
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Game-changing model to identify drugs that may slow AMD
Researchers have identified potential age-related macular degeneration drugs using a novel stem-cell based research tool.
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Prozac could be repurposed to treat age-related macular degeneration
Fluoxetine - best known as Prozac - protected the macula from inflammation and degeneration in mice and could become a future treatment.
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Team improves non-invasive visualisation of photoreceptors in eye
A new imaging technique for photoreceptors has been developed by selectively blocking light used to observe the eye.
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Vitronectin could be a promising drug target for macular degeneration
Scientists demonstrate that vitronectin is responsible of the formation of deposits in dry age-related macular degeneration and suggest inhibitors could slow disease progression.
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Developing a nanoparticle-delivered gene therapy for blinding eye disease
Ophthalmology and engineering combine in a novel nanoparticle-delivered gene therapy approach to treating wet age-related macular degeneration.
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Application of organoid technology for retinal disease modelling and drug discovery
The loss of retinal light-sensing photoreceptor cells is a leading cause of blindness and the number of individuals affected by retinal degenerative diseases is increasing with an ageing population. Currently, there are no treatments for these diseases and progress in finding new treatments is slow. This article explores the potential…
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Toll-like receptor could be targeted to treat age-related macular degeneration
Scientists have implicated toll-like receptor 2 (TLR2) in age-related macular degeneration and shown that knocking it out can improve symptoms in animal models.
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Electrical channels in retina could play role in degenerative diseases
Researchers have discovered electrical channels important in sensory cell renewal which could be studied further to develop therapies for retinal diseases.
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Revolutionary eye drops to treat age-related macular degeneration
Scientists are one step closer to developing an eye drop that could revolutionise treatment for age-related macular degeneration (AMD)...
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Macular degeneration linked to ageing immune cells
Older cells promote inflammation, abnormal blood vessel growth that can lead to blindness...
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Microglia in the retina can spontaneously regenerate
NIH discovery in mice could lead to therapies to reduce vision loss from diseases of the retina...
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Stem cell therapy discovery for age-related macular degeneration
Stem cell-derived retinal cells need primary cilia to support the survival of light-sensing photoreceptors...
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Researchers use CRISPR-Cas9 to target retinal angiogenesis.
Researchers have used CRISPR-Cas9 to target retinal angiogenesis via an adeno-associated virus to deliver genomic edits to target vascular endothelial cell growth factor...