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Aging

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New method to predict effectiveness of MSCs for cartilage repair in vitro

29 May 2024 | By Drug Target Review

Topological defects in mesenchymal stromal cell self-assembly could suggest their potential for cartilage regeneration.

article

Harnessing natural killer cells to combat age-related diseases

28 May 2024 | By Dr Robert Hariri (Celularity), Ellen Capon (Drug Target Review)

In this Q&A, Celularity’s CEO and founder Dr Robert Hariri details the preclinical research that indicates that placenta-derived unmodified NK cells and genetically modified NK cells can target and selectively eliminate cells expressing stress ligands.

news

How hematopoietic stem cells retain their regenerative potential

8 May 2024 | By Drug Target Review

Researchers found that genetic depletion of cyclophilin A results in stem cells distinctively lacking intrinsically disordered proteins.

article

How nucleolar stress accelerates aging in mice

9 April 2024 | By Dr Fernández-Capetillo (CNIO), Ellen Capon (Drug Target Review)

Dr Fernández-Capetillo shares his insights from a recent study conducted at the CNIO, elucidating how the expression of (PR)arginine-rich peptides affects ribosomal protein translation and accumulation, and how accelerated aging can be alleviated.

news

Mitochondria-targeting antibiotics reduce aging in C. elegans

27 November 2023 | By Drug Target Review

Treating C. elegans with inhibitors of small or large mitochondrial ribosomes extended their median lifespan.

article

Inflammation discovery offers hope for age-related diseases

7 August 2023 | By Fraser Owen (Drug Target Review)

Researchers have made a significant breakthrough in the field of ageing research, uncovering a key driver of chronic inflammation that accelerates the ageing process.

news

Newly discovered mechanism behind cognitive decline in aging

27 July 2023 | By Izzy Wood (Drug Target Review)

US researchers say new mechanism could lead to new drugs and therapies to treat normal cognitive decline in aging.

news

Special omega-3 fatty acid lipid plays critical role in the ageing brain

5 May 2023 | By Izzy Wood (Drug Target Review)

Scientists from Singapore have sought to understand the role of Mfsd2a in brain cells, in transporting lysophosphatidylcholine (LPC), a lipid that contains an omega-3 fatty acid

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Aging