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Newly discovered mechanism behind cognitive decline in aging
US researchers say new mechanism could lead to new drugs and therapies to treat normal cognitive decline in aging.
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Alzheimer’s disease
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Higher levels of lean muscle may protect against Alzheimer’s disease
Individuals with higher levels of lean muscle may have a reduced risk of developing Alzheimer's disease. While further research is needed to understand the underlying biological pathways and implications for clinical practice, these findings shed light on the potential role of lean muscle in protecting brain health.
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Alzheimer’s study shows improved memory and mood with enhanced neurons
Using rodent models, the researchers emphasized the potential of newly generated neurons in adulthood to serve as therapy for addressing the functional deficits and pathology associated with Alzheimer's disease.
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Transporting antibodies across the blood–brain barrier to treat Alzheimer’s disease
Researchers have found a way to ensure that new Alzheimer’s medications are delivered to the right place in the body and at the right timepoint in disease progression, so that they have the best effect.
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Research reveals protein plaques associated with Alzheimer’s disease are stickier than thought
Scientists from Rice University are using fluorescence lifetime to shed new light on a peptide associated with Alzheimer’s disease.
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Drug Target Review’s top content picks from 2022
In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.
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Novel synthetic peptides could suppress formation of harmful amyloid aggregates
German researchers have designed peptides that bind to amyloidogenic proteins linked to Alzheimer’s and type 2 diabetes, to effectively suppress both cytotoxic amyloid aggregation and amyloid cross-accelerating interactions.
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New study expands range of potential Alzheimer’s drugs
Researchers have connected the loss of alpha-B insulin receptors in brain microvessels as contributors to insulin resistance and cognitive decline, with Alzheimer’s disease.
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How neurons stimulate the brain’s microglia
A new MIT study highlights ailing neurons may activate an inflammatory response from the brain’s microglia immune cells.
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Making lab-grown brain organoids ‘brainier’
UCLA-led team discovers that using early-stage stem cells is a key to producing structures that are reliable models of disease.
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3D imaging helps to better understand the early stages of Alzheimer’s disease
Researchers have successfully characterised a part of the brain that shows the earliest accumulation of tau protein, an important biomarker for the development of Alzheimer's disease.
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New antibody shows promise in mice with Alzheimer’s disease
Scientists at UTHealth Houston have developed an agonistic antibody that reduced the amyloid pathology in mice with Alzheimer’s disease.
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Study reveals how tau impairs communication between neurons in Alzheimer’s
A new study has shown how tau weakens transmission across synapses in the brains of mice, providing insight into Alzheimer's.
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Peptide delivered by nasal spray can reduce seizure activity
A novel peptide augments the brain’s natural mechanism to help prevent seizures and protect neurons in research models of both Alzheimer’s and epilepsy.
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Novel insights into the genetic and molecular machinery that causes Alzheimer’s disease
Researchers have gained a clearer understanding of the genetic and molecular machinery in human microglia, findings that may provide insight into Alzheimer’s diseases development.