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TREM2 gene mutation poses both risk and benefits in Alzheimer’s disease
Scientists have identified that a mutation in the gene TREM2, can substantially raise a person’s risk of Alzheimer’s disease...
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Alzheimer’s disease
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Microcapsules to enhance the efficiency of genome-editing
Researchers have found that polymer and hybrid silica-coated microcapsules are efficient in genome-editing...
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Metabolic collaboration linked to Alzheimer’s disease
Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration...
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Blocking ApoE4 may prevent nerve cell death in Alzheimer’s disease
Researchers have identified that the presence of ApoE4 exacerbates the brain damage caused by toxic tangles of tau protein...
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Structure of amyloid fibrils determined with previously unachieved resolution
Researchers have displayed structural details of amyloid structures which may answer many questions on the growth of harmful deposits...
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Calcilytics as potential novel therapeutic treatments to halt Alzheimer’s disease
Alzheimer’s disease (AD) is the most prevalent form of dementia.1 The common (>95% of cases) slow-developing form of the ailment is known as late-onset AD (LOAD) or sporadic AD (SAD). The rare (
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New mindset in the search for stroke therapies
Researchers have identified a promising new avenue to explore in the search for stroke treatments...
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Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...
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New potential strategy to combat Alzheimer’s disease
Researchers have revealed the molecular mechanism behind a rare mutation has been associated with numerous neurodegenerative diseases...
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Antibody targets create potential for a unified treatment approach
Antibody targets thought to cause the most damage in neurological disorders, creates potential for a unified treatment approach...
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Artificial intelligence predicts dementia before onset of symptoms
Scientists have used artificial intelligence techniques and big data to develop an algorithm capable of recognising the signatures of dementia two years before its onset, using a single amyloid PET scan...
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Novel perspectives on anti-amyloid treatment for the prevention of Alzheimer’s
A collaboration between Prof Lucía Chávez-Gutiérrez and Prof Bart De Strooper of VIB-KU Leuven has revealed the molecular basis of the hereditary form of Alzheimer’s disease that strikes early in life.
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Biomarkers show promise as Alzheimer’s diagnostic tool
Physical biomarkers have been discovered that may help diagnose the changes to proteins found in the spinal fluid and blood of Alzheimer's patients...
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Study identifies new brain death pathway in Alzheimer’s disease
Evidence that the activation of a biological pathway necroptosis is closely linked with Alzheimer's...
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Two new genes linked to Alzheimer’s risk
Researchers have identified two genes that influence a person’s risk of developing Alzheimer’s disease.