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Screening platform reveals compounds that protect neuronal mitochondria
Researchers have developed a screening system and identified a set of compounds that protect neuronal mitochondria in mice.
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Alzheimer's
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Alzheimer’s vaccine shows promising results in bigenic mice
Researchers have created a new combination vaccine therapy that can induce strong immune responses against tau and Aβ pathologies seen in Alzheimer’s in bigenic mice.
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Exosomes used by researchers as form of novel gene therapy
A study has demonstrated that exosomes can be used as nanocarriers for therapeutic contents, as a new type of gene therapy.
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Vasomotion revealed as potential strategy to treat Alzheimer’s
A study has demonstrated that inducing brain vessel pulsations helps to clear substances from the brains of mice, so could be used to stop amyloid-β build up in the development of Alzheimer’s.
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Blood-brain barrier role in Alzheimer’s patients revealed by tissue model
A new study has found that damage caused by Alzheimer's allows toxins to enter the brain, further harming neurons.
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Encouraging drug discovery and therapeutic targets for dementia
A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.
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Crystals mapped to advance treatments for stroke, diabetes and dementia
Researchers haved mapped the crystal structure of a protein to find out how a drug latches onto it.
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Potential drug target for Alzheimer’s identified
New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.
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Neurofilament light chains detect Alzheimer’s damage before symptoms
A simple blood test reliably detects signs of brain damage in people on the path to developing Alzheimer's disease...
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Nuclear tracers help assess new drugs for neurodegenerative diseases
New nuclear medicine tracers could help medical researchers find a cure for Alzheimer's and other neurodegenerative diseases.
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New tools accurately illuminates intracellular phase separation
Researchers have made discoveries about the formation of cellular components called membraneless organelles and the key role these organelles play in cells...
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MRI scans shows promise in predicting dementia
Brain changes evident in scans before memory, cognitive decline...
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New information on the pathological mechanisms of Alzheimer’s disease
Researchers have indicated that the accumulation of pathological tau triggers a safety valve mechanism in the otherwise well-regulated cell membranes...
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Protein sequencing method could transform biological research
A team of researchers have demonstrated a new way to sequence proteins that are much more sensitive than existing technology, identifying individual protein molecules rather than requiring millions of molecules at a time
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Immunotherapy targeting blood protein fibrin
Targeting the fibrin protein could ensure that fibrin leaking through the blood-brain barrier does not cause inflammation or disease in the brain...