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Anle138b blocks toxic ion flow linked to Alzheimer’s disease
A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease by stopping toxic ion flow in the brain...
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Amyotrophic Lateral Sclerosis (ALS)
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Protein associated with ALS points to possible targets for therapeutic intervention
Scientists may have found possible targets for therapeutic interventions in the fight against Lou Gehrig’s disease.
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Phenogenetic map created for stem cell models of neurological diseases
Researchers have performed meta-analysis of neurological and neurodegenerative diseases and created an atlas of how cell characteristics are linked to their genotype...
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NIH awards $15m to support development of 3-D human tissue models
The NIH has announced 13 two-year awards totalling $15m, to develop 3-D microphysiological system platforms that model human disease...
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New gene variant identified in ALS provides treatment hope
A new study shows that a variant in UBQLN4 gene has been associated with Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS). The study also describes how this gene variant disrupts a cellular process that drives motor neuron development. This new insight opens the door to potential treatment targets for…
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Turning rare diseases into efficient targets with AI
BenevolentBio's CMO, Dr Patrick Keohane, says the industry is on the cusp of an artificial intelligence (AI) revolution...
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JPND launches €23 million call for neurodegenerative disease research
Neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are a global health, economic and social emergency.
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ALS study reveals role of RNA-binding proteins and provides new therapeutic target
20 October 2016 | By Niamh Louise Marriott, Digital Content Producer
To unravel the role RNA-binding proteins play in ALS, Yeo's team gathered skin cells from ALS patients, three with a mutation in the hnRNP A2/B1 gene...
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New protein target could treat genetic cause of ALS
15 August 2016 | By Niamh Louise Marriott, Digital Content Producer
Targeting a single protein, SUPT4H1, reduces the levels of the three toxic entities created by the C9orf72 gene expansion, the most common genetic cause of ALS...
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Researchers develop unique model for studying ALS
22 April 2016 | By Victoria White, Digital Content Producer
Researchers have developed a unique mouse model that will allow scientists to better study the genetic origins and potential treatments for ALS...
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New therapy halts progression of ALS in mice
29 January 2016 | By Victoria White
Researchers have announced that they have essentially stopped the progression of amyotrophic lateral sclerosis (ALS) for nearly two years in one type of mouse model...
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RNA-binding proteins play important role in motor neurone disease
30 October 2015 | By Victoria White
The discovery about the FUS protein could be a major milestone on the path to a treatment for both motor neurone disease and dementia...
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iPSC technology helps characterise healthy and diseased neurons
23 October 2015 | By Victoria White
Using iPSC technology, researchers created 16 different cells lines, some using cells from healthy humans and others using cells from people with ALS or spinal muscular atrophy...
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Dementia Consortium funds project focusing on ALS and FTLD
16 September 2015 | By Victoria White
A team at the International Centre for Genetic Engineering and Biotechnology (ICGEB) will join forces with MRC Technology to take on the project...
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Gene therapy gives long-term protection to photoreceptor cells in retinitis pigmentosa model
15 July 2015 | By Victoria White
Scientists have shown that gene therapy can give protection to the light-sensitive photoreceptor cells responsible for colour vision in retinitis pigmentosa...