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New findings could influence asthma drug development
Researchers have revealed that genetically enhanced expression of GSDMB causes a disturbed interferon-response.
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Asthma
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New insights about the influence of STAP-1 on immune cell activation
The new findings could lead to a therapeutic target for immune-related disorders, like multiple sclerosis.
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Helper T cells may hold key to precision allergy treatment
US researchers have connected a rare T cell called Th9 with treating allergies, testing in mouse models with asthma.
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The role immunological memory plays in fighting disease
US research about immunological memory may help development of potential vaccines or immunotherapies for cancer and various inflammatory diseases.
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How to make asthma drugs last longer
US researchers uncover how to make asthma and COPD medication more potent, which could also improve how long they work in patients who need frequent doses.
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CRISPR screens and novel drug targets
According to a new study, a metabolic enzyme studied in cancer biology is key for T-cell function, offering a novel target for anti-inflammatory therapeutics. Dr Jeffrey Rathmell and Ayaka Sugiura from Vanderbilt University in the US discuss their study with Drug Target Review and why inhibiting or genetically deleting the…
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CRISPR screen unveils enzyme target for inflammatory diseases
Scientists used a CRISPR-based screen to find that inhibiting MTHFD2 reduces disease severity in inflammatory disease models.
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New models for intranasal drug delivery
In this article, Dr Jon Volmer and Dr Jon Lenn discuss a new approach to formulation models to test drug delivery based on reconstituted nasal epithelium.
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Asthma vaccine shows success in pre-clinical studies
A new conjugate vaccine has shown promise at protecting mice against the effects of cytokines associated with asthma.
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Two novel molecules to potentially combat asthma discovered
Researchers have discovered that giving L-tyrosine and PCS to mice prevents lung inflammation and an allergic asthma response.
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New inhaled therapy could treat deadly impacts of asthma
Scientists have developed an inhaled treatment for asthma that prevents excess mucus from building up in mice.
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Novel bronchodilator could be used for control of asthma
Study identifies a promising new compound that can open constricted airways and could be a promising treatment for obstructive lung diseases.
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Unlocking the power of the microbiome in life sciences R&D
Anthony Finbow explains how applying microbiome-based evidence to disease modelling will enable researchers to devise more targeted treatments.
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Mystery glycoprotein could prevent respiratory distress
According to researchers, the DMBT1S8 molecule can halt inflammation in the respiratory tract through its interaction with the Siglec-8 receptor on immune cells.
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Tregs produced by mesenchymal stromal cells with novel technique
By culturing blood cells with mesenchymal stromal cells (MSCs), researchers induced the production of cells with the same functionality as Tregs.