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Mitochondrial protein revealed as target for cardiovascular disease
According to new research, the protein ALDH4A1 is a possible therapeutic target and diagnostic biomarker for cardiovascular disease.
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Atherosclerosis
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CARD8 protein could be novel atherosclerosis drug target
Researchers demonstrate that the CARD8 protein plays a key role in regulating the inflammation that causes atherosclerosis and other inflammatory diseases.
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Putrescine could be a therapy for chronic inflammatory diseases
Research has identified that putrescine, which aids macrophages in clearing dead cells, is lacking in atherosclerosis animal models and could be a potential therapeutic for the condition.
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PCSK6 enzyme plays a key role in vascular disease, according to research
A new study has demonstrated that the enzyme proprotein convert subtilisin/kexin 6 causes structural and functional remodelling in vascular disease, so could be a new therapeutic target.
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Unhealthy gut microbiomes in mice remodelled into more healthy ones
Scientists have shown that there are molecules to remodel the gut microbiome and turn an unhealthful gut into a more healthful one for the first time.
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Study discovers key process in the cause of cell aging
Researchers have identified a key process behind senescence, or why cells age, which could be used to improve treatments for cancer.
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Omega-6 fatty acid could help fight heart disease
Scientists have shown that an omega-6 polyunsaturated fatty acid could halt the progression of atherosclerosis, a leading cause of heart disease.
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Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Aortic plaques may contribute to liver disease progression
Aortic atherosclerotic plaque inflammation may contribute to the progression of non-alcoholic fatty liver disease to liver fibrosis...
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Computational models provide genetic insight into atherosclerosis
Researchers find a gene in artery wall activated by lipids associated with coronary artery disease...
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Targeting BAFF reduces the development of atherosclerosis
The researchers identified that BAFF to have anti-inflammatory properties, which has a positive effect on plaque size and atherosclerosis...
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E06 antibody blocks inflammation from hardened arteries and liver disease
Study uncovers new potential therapeutic approach for a number of diseases linked to inflammation, including atherosclerosis, aortic stenosis and hepatic steatosis...
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Organ-on-a-chip device successfully models heart disease
A new device that models atherosclerosis can help researchers better understand the disease, develop therapies and diagnose blood health...
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TwoXAR and University of Chicago in atherosclerosis collaboration
25 May 2016 | By Victoria White, Digital Content Producer
TwoXAR is to collaborate with the Department of Medicine at the University of Chicago to identify potential new medicines for treating atherosclerosis...
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Controlling cholesterol metabolism in pancreatic cancer cells reduces metastasis
4 May 2016 | By Victoria White, Digital Content Producer
The findings of a new study suggest a class of drugs previously developed to treat atherosclerosis could be repurposed for treatment of pancreatic cancer...