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Cancer Research

Red blood cells flowing with too many white blood cells, indicating leukaemia

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Associations of AML MRD levels with posttransplant clinical outcomes

9 May 2024 | By Drug Target Review

Patients with no detectable FLT3 mutations had the best outcomes after an allogenic hematopoietic cell transplant.

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New methodologies to find microbiome biomarkers

3 May 2024 | By Drug Target Review

Confounder control and quantitative profiling revealed misleading associations between microbial markers and colorectal cancer development.

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Unlocking the potential of antibody drug conjugates

1 May 2024 | By Dr Jamie Rich (Zymeworks), Dr Paul Moore (Zymeworks), Dr Raffaele Colombo (Zymeworks)

Zymeworks’ Dr Paul Moore, Dr Raffaele Colombo and Dr Jamie Rich discuss how advancements in ADCs are redefining cancer treatment. They elucidate the innovative strategies that are being developed to improve drug stability and how personalised medicine approaches are optimising outcomes for individual cancer patients, offering new hope across several…

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First animal model for Kaposi sarcoma developed

30 April 2024 | By Drug Target Review

The mouse model provides a new understanding of the fundamental aspects of KSHV, which will enable drug and vaccine development.

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How tumours prevent formation of immune responses

25 April 2024 | By Drug Target Review

Scientists found that preventing the effects of prostaglandin E2 could be an effective therapy to overcome tumour defence.

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Mini-colons reveal complex process of tumorigenesis ex vivo

25 April 2024 | By Drug Target Review

The mini-colons are topobiologically complex, can be induced to develop tumours in targeted areas and reduce the use of animal models.

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New single-cell lipidomics method may unlock cancer treatments

24 April 2024 | By Drug Target Review

A new method for a fragmentation-based identification of lipids could enable the study of cancer cells in detail not seen before.

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Targeting RAS to overcome FLT3 AML drug resistance

22 April 2024 | By Drug Target Review

It was discovered that targeting RAS proteins prevent cancer cells from using different signalling pathways to escape cell death.

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Developing the next generation of antibody drug conjugates

22 April 2024 | By Ellen Capon (Drug Target Review), Léo Marx (Debiopharm)

In this Q&A, Léo Marx, Medicinal Chemistry Project Manager at Debiopharm, details how the therapeutic window of ADCs can be impacted, how we can overcome the challenges associated with achieving site-specific bioconjugation, and other essential considerations for optimising ADC performance.

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Drug-loaded 3D printed films could revolutionise liver cancer treatment

18 April 2024 | By Drug Target Review

The new films killed over 80 percent of cancer cells, reduced recurrence rates and minimised undesirable chemotherapy side effects.

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Explaining uveal melanoma’s resistance to conventional immunotherapies

17 April 2024 | By Drug Target Review

Researchers have developed a new tool called ‘Uveal Melanoma Immunogenic Score’ to predict which patients will respond to adoptive therapy.

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New screening method for HPV-positive head and neck cancer

17 April 2024 | By Drug Target Review

A urine-based test that detects ctDNA from HPV-positive head and neck cancers could facilitate its early detection.

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The immune system’s role in lung cancer risk

17 April 2024 | By Dr Diego Chowell (Ichan Mount Siani), Dr Robert Samstein (Ichan Mount Siani)

In this Q&A, Ichan Mount Siani researchers Dr Diego Chowell and Dr Robert Samstein share their new insights about the associations between human leukocyte antigen (HLA) class II loci and lung cancer risk.

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Pioneering the advancement of pre-targeted radioimmunotherapies

16 April 2024 | By Ellen Capon (Drug Target Review), Francesco Sergi-Lindell (PreTT)

Although pre-targeting is still in its infancy, it has immense potential to increase state-of-the-art radioligand therapies. In this Q&A, PreTT reveals how their pre-targeted RLTs surpass traditional methods, transforming cancer treatment.

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Elucidating the mechanism that initiates cancer cachexia

15 April 2024 | By Drug Target Review

The new findings could lead to new therapeutics and a method to diagnose pancreatic cancer earlier, improving its prognosis.

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Cancer Research