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Targeting cancer cells in early hypoxia
Inhibiting the LDHA and GOT1 enzymes could prevent cancer cells’ ability to produce energy, without affecting healthy cells.
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Cancer Research
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P47 suppresses metastasis of HER2-positive breast cancer
Results from an in vivo CRISPR knockout screen, targeting genes involved in autophagy, could lead to new therapies.
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How fusion proteins drive paediatric cancer
Researchers discover that fusion proteins and a gene regulatory protein complex interact through disordered domains.
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New algorithm identifies high-risk precancerous lesions
Researchers have developed an algorithm which could improve diagnostics of ovarian high-grade serous carcinoma.
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Breakthrough for pancreatic cancer treatment
Researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.
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Scalable precision design targeting complex product profiles
We had the privilege of speaking to Dr Víctor Sebastián Pérez, Associate Director of Computational Drug Design, following his presentation at ELRIG UK 2023. He shares his insights into how Exscientia is using AI to design drug candidates for cancer treatment.
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Potential new treatment options for KSHV-associated cancers
Treatment with Palbociclib and a compound targeting CAD increased survival to 100 percent for selected lymphoma cell lines.
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Colon cancer: distinct transcriptional programmes identified
Researchers elucidate the significant role of CDX2 in regulating stemness and differentiation, particularly in the proximal colon’s epithelial cells. This research encourages new combinations of existing drugs, that inhibit both the BRAF and KRAS genes, to be explored.
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The future of cancer immunotherapy with Elicio Therapeutics
In this exclusive interview with Dr Christopher Haqq, Executive Vice President, Head of Research and Development, and Chief Medical Officer of Elicio Therapeutics, we explore the latest in Cancer Immunology Research. The study highlights the promising preclinical data demonstrating the potential of TCR-T cell therapy in combination with lymph node-targeted…
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Potential for targeted therapies based on the gigaxonin pathway
Researchers have discovered that higher expression of gigaxonin suppresses aggressive growth of human head and neck cancer cells.
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Newly discovered role of AF1q in neuroblastoma
Researchers have identified that AF1q is highly expressed in neuroblastoma, and could be used to destabilise N-Myc.
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A promising new treatment strategy for hepatoblastoma
A combination therapy of vincristine, irinotecan and panobinostat, tested in high-risk, relapsed or refractory HB spheroids, decreased tumour marker levels.
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Insights into cellular therapies for cancer treatment
Many exciting developments are expected to take place in immunotherapy and oncology in the next few years. We had the privilege of discussing the opportunities of various cell therapies with Dr Suresh Nair, Physician in Chief, who elucidates how Lehigh Valley Topper Cancer Institute is directing research towards better treatments,…
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Identification of an immune biomarker for liver cancer
New immunotherapies may be developed for patients with HCC associated with steatotic liver disease, with TREM1 suggested as a target.
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A new genetic biomarker to predict immunotherapy success
Tumours with a greater IGR burden could respond better to immune checkpoint blockades, advancing precise treatments for patients.