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Cancer Research

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The implications of EN-1 overexpression in late-stage PDAC

15 February 2024 | By Drug Target Review

Using tumour organoids, researchers identified that overexpression of Engrailed-1 blocked genes associated with natural cell death.

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Improved CAR T-cell immunotherapy for acute myeloid leukaemia

14 February 2024 | By Drug Target Review

Researchers have created dual-targeted CARs, which performed better than single-targeted CARs in both in vivo and in vitro experiments.

whitepaper

Beyond the lab: immuno-oncology

14 February 2024 | By Drug Target Review

Read this in-depth analyses and insights from leading experts in the field focusing on treatments, new technologies and engineered bacteria.

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Integrin αV and β5 partner to drive cancer cell growth

7 February 2024 | By Drug Target Review

A novel cellular mechanism has been uncovered with the use of CRISPR gene-tiling technology, which could advance oncologic therapies.

news

Reducing drug resistance in acute myeloid leukaemia patients

6 February 2024 | By Drug Target Review

Researchers conducted a proteogenomic characterisation and found that drug exposure changes drug sensitivity.

news

Organoid drug testing predicts bowel cancer treatment response

6 February 2024 | By Drug Target Review

A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.

news

How the DA subtype of Wilms tumour resists chemotherapy

5 February 2024 | By Drug Target Review

Researchers suggest that DA histology slowly emerges by accumulating burdens of DNA damage and copy number aberrations.

news

Augmenting cancer immunogenicity through MHC class I

31 January 2024 | By Drug Target Review

A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.

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Targeting Ku70 could improve bowel cancer treatment

29 January 2024 | By Drug Target Review

The Ku70 protein prevents cancer cells from becoming more aggressive and metastasising. It could also be used as an immune biomarker.

article

Therapeutic peptide developed for triple-negative breast cancer

25 January 2024 | By Ellen Capon (Drug Target Review)

Scientists demonstrate how disrupting the Cx26 molecular complex in triple-negative breast cancer cells slowed tumour growth.

news

New immunological pathway to treat bone tumours

25 January 2024 | By Drug Target Review

Researchers observed significant upregulation of Siglec-15 in the tumour microenvironment in bone tumour samples from breast cancer patients.

news

The potential of PD-L2 inhibitors for cancer treatment

24 January 2024 | By Drug Target Review

Researchers discover that blocking PD-L2 in senescent cells increases the efficacy of chemotherapy in mouse models.

news

PLK4 inhibition: a new therapeutic for AML

24 January 2024 | By Drug Target Review

PLK4 inhibition could be a novel therapeutic for an acute myeloid leukaemia subtype carrying the TP53 mutation.

news

Advancing personalised medicine with a cholangiocarcinoma model

23 January 2024 | By Drug Target Review

A patient-specific organ-on-a-chip model of cholangiocarcinoma, with its tumour microenvironment, helps to predict therapy response.

news

How PD-1 promotes Merkel cell carcinoma progression

23 January 2024 | By Drug Target Review

Inhibiting mTOR signalling and neutralising mtROS suppressed MCC-PD-1-mediated tumour proliferation in mice.

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Cancer Research