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Promising anticancer molecule identified
Researchers have identified a DNA-derived molecule that binds to and inhibits the function of CYP24 and shows promising antiproliferative activity.
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Cancer
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Listeria-based booster improves vaccine’s protection against recurring cancer
New research has shown that using viral and bacterial vaccine approaches together is safe and far more effective at fighting the cancer than either approach by itself.
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Cancer immunotherapy capable of regulating tumour immunophenotypes
Researchers have found that small-molecule activation of innate immunity induces the infiltration of immune cells into cancer cells.
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Immune cell populations have been mapped to provide new insights into how the immune system works
Two new papers from the Human Cell Atlas shed new light on the types and traits of immune cells that can be found in the human body, from developmental stages to adulthood.
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Study reveals cellular diversity of oesophageal tissue
Researchers defined 11 subsets of cells found in the oesophagus of mice. These findings could potentially help clinicians diagnose or treat certain types of cancer.
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Whole genome sequencing study reveals hidden insights about the causes of cancer
DNA analysis of thousands of tumours has uncovered insights about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.
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Extracellular vesicles: a new target for understanding endocrine disorders
Scientists at the Endocrine Society have found extracellular vesicles may offer new insights into treating endocrine disorders.
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Key takeaways from the AACR Meeting 2022
Drug Target Review's Editor Victoria Rees brings you the highlights from the American Association for Cancer Research Meeting 2022.
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Simple delivery method that enhances a promising cancer treatment
Scientists have developed a delivery method that enhances treatment by adding CAR T cells and specialising signalling proteins to a hydrogel that is injected next to a tumour.
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Viewing disease through the lens of memory B cells: improving cancer and infectious disease treatment
Looking at disease through a patient’s memory B cells can reveal vulnerabilities within pathogens. In this article, Dr Purnanand Sarma, President and Chief Executive Officer of Immunome, explores how advancements in memory B-cell antibody-based treatments will improve our understanding of how these cells can aid in fighting cancer and other diseases.
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Study highlights the essential role of dendritic cells in immunotherapy
Researchers have discovered how immune system dendritic cells are key to maintaining and regulating response to immunotherapy.
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Drug Target Review Antibodies ebook 2022
This ebook includes articles about antibody-based therapies that could protect against cancer by utilising a patient's memory B cells. Also included is a piece on an intranasally-delivered monoclonal antibody treatment to potentially protect against SARS-CoV-2.
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Drug Target Review Immuno-oncology ebook 2022
Included in this ebook are articles on how to develop more effective CAR T cells by modifying the CAR design and why recent findings about ferroptosis in cancer cells could enhance immunotherapies.
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Uniting industry and academia for phenotypic drug discovery
A collaboration between Exscientia and the University of Oxford Target Discovery Institute (Oxford TDI) has been established to source cellular functional assays from the global academic community, with the goal of developing novel screens and identifying targets and therapeutic candidates for unmet medical needs. Here, Dr Denise Barrault, Director of…
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Driving precision neurology forwards with iPSCs and new assays
Precision medicine in neurology is limited by a dearth of clinically relevant models. However, here Dr Evangelos Kiskinis, Assistant Professor at Northwestern University Feinberg School of Medicine, discusses how new technologies such as bioelectronic assays enable real-time, long-term analysis of neurological diseases in a dish, offering a pathway towards identifying…