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Team creates new nanoplatform for delivering drugs into T cells
Researchers have developed a pH-sensitive drug delivery system in T cells using C-terminal dendrimers with Phenylalanine.
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Cancer
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CAR T-cell implant effective at attacking cancer in pre-clinical study
Researchers have created an implantable biotechnology that produces and releases CAR T cells for attacking cancerous tumours.
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Enhanced way to generate effective personalised cancer vaccines revealed in study
Scientists have created a pipeline for identifying, prioritising and evaluating potential tumour antigens for personalised cancer vaccines.
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Enzyme revealed as promising new target for cancer immunotherapies
A new study has highlighted an enzyme called ART1 as a promising target for immunity-boosting cancer treatments.
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New findings could improve personalised cancer immunotherapies
A new study has highlighted that gene expression profiling could enable rapid identification of anti-tumour immune cells for personalised immunotherapy.
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Tool developed to fight cancer rapidly and effectively
Scientists from Northwestern University have developed a new technology platform that could bring individualised cell therapies to cancer patients.
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Discovery could advance CAR T-cell therapy
Scientists have found a way to “supercharge” tumour-attacking T cells, which could improve the effectiveness of cell-based cancer immunotherapy and expand the number of cancers it can treat.
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Biohybrid micro and nano robots could revolutionise drug delivery
A recent paper highlights how tiny robots with living parts can be designed to effectively deliver drugs to body tissues.
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How RNA molecules can control repair of human DNA in cancer cells revealed
New research from the Karolinska Institutet shows that RNA molecules have a much broader function in the development of cancer.
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Cannabidiol analogue could enhance chemotherapy by preventing neuropathic pain
A new study has revealed a cannabidiol analogue can possibly prevent neuropathic pain induced by chemotherapy, as well as being beneficial against cancer.
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Study identifies key regulator of cell differentiation
Long-awaited findings about cell differentiation will be relevant in understanding normal development and may also be useful in cancer research.
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Novel CAR T-cell therapy for B-cell cancers shows promise in vivo
A new CAR T-cell therapy for B-cell cancers promises to reduce the antigen escape currently found in therapies that only target CD19.
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Avacta selects chemotherapy drug candidate for pre-clinical development
Avacta Group announced that the chemotherapy candidate AVA3996 will be developed with a view to a first-in-human clinical trial beginning in 2023.
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Virtual method enables screening of billions of chemical compounds
A new platform, named Virtual Synthon Hierarchical Enumeration Screening, has been developed by researchers to efficiently discover drugs.
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CRISPR screens and novel drug targets
According to a new study, a metabolic enzyme studied in cancer biology is key for T-cell function, offering a novel target for anti-inflammatory therapeutics. Dr Jeffrey Rathmell and Ayaka Sugiura from Vanderbilt University in the US discuss their study with Drug Target Review and why inhibiting or genetically deleting the…
