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Simulations and fragment screening reveal binding sites on tubulin protein
A combination of computer simulations and fragment screening have uncovered 27 molecular binding sites on tubulin, a protein of the cell cytoskeleton.
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Global biochip market set to increase at CAGR of 12.5 percent
According to new research, the biochip market will grow as a result of the rising demand for personalised medicine.
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MIS hormone shown to suppress ovarian follicle development
Researchers have shown how the MIS hormone can prevent ovulation in females, making it a potential new form of contraception.
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Small-molecule cocktail could improve use of stem cells in treatments
Researchers have shown that Chroman 1, Emricasan and trans-ISRIB, in combination with polyamines, are effective at protecting induced pluripotent stem cells from stress.
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New developments in the research field of immuno-oncology
The exciting potential of immunotherapy for cancer treatment continues its exploration and here, Drug Target Review investigates three of the latest pre-clinical developments in immuno-oncology research.
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Sanguinarine shows promise against triple-negative breast cancer
A new study in cell cultures has shown that the sanguinarine plant compound could be used to treat people with triple-negative breast cancer.
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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
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Structure of PLEKHA7 protein domain imaged, presenting cancer drug target
A range of imaging and computational techniques were used by researchers to discover the structure of the PH domain of PLEKHA7.
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Assay developed to detect cathepsin B in blood samples
Scientists have created an assay to detect the protein cathepsin B in blood, a biomarker for a range of diseases.
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Team identifies potential drug to repurpose against melanoma
Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
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Method to make cell cultures act more like normal cells discovered
Scientists have shown that culturing cells with a modified serum could allow drugs to be screened for toxicity earlier during research.
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Revealed structure of enzyme could progress cancer research
Researchers have elucidated the 3D structure of the Taspase 1 enzyme, known to be involved in a range of cancers.
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Tumour cell vaccine strategy developed for neuroblastoma and melanoma
A combination of checkpoint and small molecule inhibitors showed success at targeting Myc oncogenes in mouse neuroblastoma and melanoma models.
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Immunosurveillance and the importance of CD4 T cells in developing cancer vaccines
In this article, Dr Lien Lybaert describes how the innate and adaptive immune system work together to produce an effective and durable antitumour response. She explains why the best strategy for personalised cancer therapy is therefore to identify major histocompatibility (MHC) binding epitopes to cover the full antigenic repertoire of…
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Glycolytic-pathway inhibition and CTLA-4 blockade to improve immuno-oncology
In this Q&A, Dr Taha Merghoub discusses how a combination of glycolytic-pathway inhibition and immune checkpoint blockade using anti-CTLA-4 in patients with highly glycolytic tumours could present a personalised approach for immuno-oncology.