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Researchers develop novel way to identify new cancer drugs
A team has developed a new way to discover peptide therapeutics that inhibit HDAC enzymes and are effective against cancer.
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Targeting PEG2 reverses age-related cognitive decline in mice
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
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New probes shine a light on the role of four-stranded DNA in human cells
A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.
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Study shows how to improve cancer treatment with anti-OX40 antibodies
New insights into the mechanisms of anti-OX40 antibodies could enable their therapeutic activity to be manipulated to treat different tumours.
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A single approach to creating effective cancer and autoimmune disease therapeutics
Dr H. Michael Shepard, CEO and CSO of Enosi Life Sciences, discusses the similarities between cancer and autoimmune diseases, highlighting how this knowledge could be used to enhance treatments.
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Immunotherapy with radiotherapy could improve outcomes of cancers in liver
Researchers have discovered that in mice with cancers in the liver, immunotherapy and radiotherapy prevented T-cell death.
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NIK could be key to enhancing the effects of immunotherapy
Immunology study shows that NF-kappa B-inducing kinase (NIK) is critical to T cell metabolism and the antitumour immune response.
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Researchers reveal protein function that could improve chemotherapy
Scientists have found that the RFWD3 protein could play a role in recruiting DNA key repair and signalling factors, impacting chemotherapy.
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Single interaction could explain the disparity in COVID-19 effects
According to researchers, an interaction between host microRNA and SARS-CoV-2 could be responsible for the range of disease severities.
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Researchers develop computer algorithm to identify cancer cell lines
Scientists have trained a computer algorithm to identify differences in cancer cell lines based on microscopic images, preventing the misclassification of cells.
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The Editors’ views: Drug Target Review’s 2020 round-up
The Junior Editors of Drug Target Review, Victoria Rees and Hannah Balfour, discuss some of the most noteworthy news and announcements from this year.
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Studies in mice reveal link between obesity and tumour growth
New research has provided a metabolic atlas for insights into obesity and tumours' ability to hide from the immune system.
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Synthetic llama antibodies used to rescue mutated proteins
Engineered deubiquitinases combines a synthetic nanobody that recognises a protein that can rescue proteins tagged for destruction.
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A label-free imaging technique for drug evaluation at single‑cell level
This article provides a brief overview of the technical and conceptual advantages of Raman spectroscopy, a label-free imaging technique that is being increasingly used for the purpose of drug evaluation.
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Biosynthetic polysaccharide-based drugs and nutraceuticals from non-animal sources
Glycosaminoglycans (GAGs) are a class of naturally occurring polysaccharides that play vital roles in cellular functions. GAGs (eg, hyaluronic acid, heparosan, chondroitin, chondroitin sulfate, heparan sulfate and heparin) have also been utilised in biopharmaceutical and nutraceutical industries. Animal-sourced GAGs can contain process impurities and contaminants, which may result in adverse…
