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Study aims to boost antitumoral activity of compound in Amazon plant

1 November 2019 | By Rachael Harper (Drug Target Review)

Scientists seek to design therapeutically more potent chemicals from alkaloids produced by the plant, Uncaria guianensis, which could aid in combatting tumours.

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Histones revealed by study as critical for cell identity

31 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have shown that histones are vital in silencing genes and that their position is inherited in new cells, providing insight into how cancer cells can become resistant to therapy.

news

Researchers reveal how body repairs damaged DNA

28 October 2019 | By Victoria Rees (Drug Target Review)

A team has imaged the process that the body uses to stabilise DNA, which could be used to develop therapies for conditions such as cancer.

news

Microprotein revealed to regulate cell stress by study

25 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have discovered a microprotein that acts as a regulator of cell stress, which could be used in developing therapies for a wide range of conditions.

news

T cell immune system regulator identified by researchers

25 October 2019 | By Victoria Rees (Drug Target Review)

A new study has discovered two enzymes which regulate a biological switch that controls the immune system, providing the potential to develop targeted therapies.

news

Reasons why targeted immuno-oncology drugs sometimes fail discovered

24 October 2019 | By Rachael Harper (Drug Target Review)

A new study has shown the specific cellular mechanisms that limit the ability of CD8 T cells to infiltrate the tumour microenvironment, which could guide new immunotherapeutic strategies in cancer.

news

Machine-learning algorithm developed to aid in epigenetic drug discovery

23 October 2019 | By Rachael Harper (Drug Target Review)

A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.

news

Study reveals how circulating tumour cells target organs

23 October 2019 | By Victoria Rees (Drug Target Review)

Regulator genes and proteins have been identified on circulating tumour cells in mice which allow them to target other organs in the body.

news

New way to target treatment-resistant cancers identified

22 October 2019 | By Rachael Harper (Drug Target Review)

A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.

news

Collaborative enzyme study could lead to a target for cancer therapeutics

21 October 2019 | By Rachael Harper (Drug Target Review)

A new study into the enzyme Cdc34 may make it possible to target the enzyme specifically to develop new cancer therapeutics.

news

New drug shows promise as immune therapy for cancers

17 October 2019 | By Rachael Harper (Drug Target Review)

A therapy has been developed which uses a synthetic RNA molecule developed to fight viruses to trigger an immune response against tumours in mice.

news

Selective inhibitor could reduce resistance to cancer therapies

16 October 2019 | By Victoria Rees (Drug Target Review)

A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.

news

Researchers develop new immuno-oncology technique

15 October 2019 | By Victoria Rees (Drug Target Review)

A team has used viral gene editing and CRISPR to form a system that marks tumours for destruction, potentially improving immunotherapies.

news

Best targets for immunotherapy identified by new model

10 October 2019 | By Rachael Harper (Drug Target Review)

A new algorithm has been developed which personalises which cancer mutations are best targets for immunotherapy.

news

New technology invented to streamline drug discovery

8 October 2019 | By Rachael Harper (Drug Target Review)

New protein-painting technology could lead to developing cancer immunotherapy medicines that can be administered as a pill.

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Cancer