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Protein receptor linked to cell death imaged for the first time
Researchers have imaged an inflammation-related protein receptor on cell membranes which could inform future drug designs to prevent cell death.
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Cancer
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Anticancer activity delivered by targeting mitochondrial cell regulator
Disruption of the MFF-VDAC1 complex could lead to a potential therapeutic target for cancer.
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Three-dimensional structure of the genome replication machine discovered
New research provides insights into how cancers can arise when DNA polymerase delta is not functioning properly.
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A biosynthetic pathway to identify new drug candidates
A new process for identifying and biosynthesising drug candidates has been discovered by researchers at the Carl R Woese Institute for Genomic Biology.
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High-throughput method used to identify cancer drug candidates
A study using high-throughput screening has revealed some promising compounds that could be used in future cancer treatments.
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Method to reactivate ‘tumour suppressor’ genes discovered
A new method to reactivate 'tumour suppressor' genes switched off by cancer cells could lead to new targeted biotherapies for cancer.
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Device using small biomagnets could result in faster drug discovery
A new platform brings together genome editing with magnetic cell sorting to reveal new drug targets for cancer and regenerative medicine.
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Vital cell metabolic pathway regulator identified by study
A study has revealed that the mitoNEET protein controls a metabolic and functional gateway on mitochondria, which could provide a drug target for cancer.
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Therapeutic antibodies in cancer therapy
Monoclonal antibodies have shown great promise in the treatment of various cancers. This article discusses how therapeutic antibodies are produced and the various treatment strategies that are currently being adopted.
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Next generation sequencing for cancer precision medicine
The systematic successful treatment of cancer still eludes us and in an effort to refine this area of targeted medicine, Lauri Paasonen and colleagues explore the potential of using patient-derived cells (PDCs) for devising a personalised treatment strategy for solid tumours.
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Hitting the target – utilising recombinant antibodies for viral research
Having worked in antibody research for over 20 years, Gary McLean has seen how the industry has progressed and understands the potential that antibodies have in the future of medicine. Nikki Withers hears how the focus has shifted from discovery to genetic sequence manipulation and how this can be applied…
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Study finds B cells could improve immunotherapies for cancer
Researchers have discovered that B cells aid T cells in fighting cancer, which could be an area of development for immunotherapies.
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Largest genome sequencing project launched in UK
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
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Inflammatory regulator molecule identified by study
Researchers have discovered an enzyme that is pivotal in deciding whether cells survive or die in inflammatory diseases, so provides a drug target.
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New biological targets could lead to therapies for drug-resistant cancers
A study on how Polycombs regulate cellular identity could lead to alternative treatments for patients with drug-resistant cancer.
