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New evidence shows cytotoxic T cells can destroy targets of large mass
New study shows the ability of CD8+ cytotoxic T cells to penetrate a large target, which opens avenues to destroy solid cancers.
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Cancer
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Five latest developments for models
The use of models is a key feature of preclinical studies and in recent months there have been several new advancements in this area. This article investigates five of the latest developments.
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Secondary structures study could lead to making cancer cells vulnerable
Researchers have used machine learning to discover that the two most widespread DNA structures cause genome mutations that lead to cancer.
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Discovering new routes to cancer drug discovery with neutrons
From the world’s flagship neutron science facility, Institut Laue-Langevin (ILL), Matthew Blakeley shares insights into how they are harnessing the power of neutrons to aid their search for new cancer treatments.
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Study identifies protein pathway key in cancer growth
Researchers have discovered a pathway which when blocked can cause cancer cell death, pointing to new therapies.
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Study reveals antioxidant role in spread of lung cancer
Researchers have discovered that lung cancer cells metastasise using antioxidants, informing potential future therapies.
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Potential drug target for Alzheimer’s identified
New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.
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Gene discovery could make cancer therapies more effective
A recent study has identified the DBC1 gene which leaves cancer cells more exposed to therapies.
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Scientists have discovered important redundancies in T cells
Redundancies have been discovered in the biochemical signalling pathways of immune cells which could impact cancer immunotherapy.
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New model found to improve drug development in pre-clinical trials
Researchers have successfully created a multi-organ in vitro model to test toxicity and efficacy of drugs.
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Study identifies two enzymes which protect tumour cells
Researchers have found an enzyme and its counterpart which inhibit T-cells from attacking tumour cells.
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Biomarkers for potential cancer immunotherapy identified
Researchers have found two biomarkers which play a significant role in the invasion of tumours by T-cells.
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Image-based characterisation of cancer biotherapeutics
Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to progress drug discovery campaigns and identify the most promising candidates for antibody-based therapies.
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First in vitro lung cancer test launched
A new in vitro lung cancer diagnostic test has been launched by Roche Diagnostics to provide improved detection of cancer.
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CRISPR/Cas9-engineered cancer models: the next step forward for targeted cancer therapy
The advent of CRISPR/Cas9 gene editing, together with the plummeting cost of whole-genome sequencing, has cleared a path for the development of customised cancer cell models. Here, we discuss recent developments in the field and challenges associated with targeted-therapy resistance.