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Protein mTOR regulated by Src in cancer growth
Researchers at Baylor College of Medicine and Texas Children's Hospital have identified a connection between cancer proteins mTORC1 and Src...
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RNA circuits making gene therapy more effective
Circuits consisting of single-stranded RNA have been shown to be make gene therapy more effective, and allows precise control over the therapy...
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Cancer stem cells use normal genes in abnormal ways
Researchers have identified that MHC Class I-high, CDK1 high molecules may be at the heart of conditions including melanoma, pancreatic and colon cancers...
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Elrig 2018: Drug discovery using small and large molecules
The Drug Target Review team are at Elrig Drug Discovery 2018 in the London ExCel...
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Researchers develop a potential tool for efficacious targeted cancer therapy
Researchers have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses...
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Prostate and lung cancers driven by common mechanisms
Lung and prostate small cell carcinomas are driven by common mechanisms, which could lead to the development of one treatment for all small cell cancers...
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Cancer immunotherapy researchers win Nobel prize
Researchers from the US and Japan have received the Nobel prize in medicine for their development of cancer immunotherapy using PD-1 and CTLA-4...
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Cancer vaccine shows promise for HER2-positive cancers
Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers...
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DNA vaccine shows promise for cancer immunotherapy
DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...
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‘Paintable’ chemotherapy for melanoma shrinks tumours
A hydrogel incorporating transfersomes and chemotherapy drugs incorporated with some intravenous medication may be the best treatment for melanoma...
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Cancer cells hide to evade immunotherapy
Cancer cells have been found to evade immunotherapy by hiding behind human leukocyte antigens, with researchers identifying therapies to prevent relapse...
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New understanding of T-cell receptor behaviour presents challenge for immunotherapies
Researchers in the U.S. have made a surprising discovery about the binding behaviour of a particular T-cell receptor, with complicated ramifications for immunotherapy developers.
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Np63a should be targeted in squamous cell carcinomas
A team of researchers have identified that to target p63, both TGFB2 and RHOA tumour suppressor genes should be activated...
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Scientists develop means to manipulate nuclear pore numbers
Researchers in California have developed a method to facilitate control of nuclear pore numbers in cells. The capability is expected to glean valuable information to aid cancer treatment.
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Fewer side effects from cancer drugs promised
Researchers from Copenhagen have developed a method of accurately using proteins to track the path of a drug through the body to ensure its safety...