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Blood test may identify cancer patients who won’t respond to immunotherapy
Patients who are unlikely to benefit from a commonly used immunotherapy for bladder cancer could be identified by a simple blood test...
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Research team develops predictor for immunotherapy response in melanoma
Researchers have developed a gene expression predictor that can indicate whether melanoma in a specific patient is likely to respond to treatment with immune checkpoint inhibitors...
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Compound with selectivity for cancer cells without p53 identified
The compound has been shown to target cancer cells without the p53 gene, and does not affect healthy cells...
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GC4419 could prevent debilitating side effect of cancer treatment
Researchers are reporting on a new drug that can treat the painful and debilitating side effect of severe oral mucositis (SOM)...
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CRISPR technique skips over portions of genes that can cause disease
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
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RUNX proteins essential for DNA repair
The research team identified that the more the DNA was damaged, the more RUNX proteins bound to DNA repair intermediaries...
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Targeting the growth signals of ‘undruggable’ cancers
Dr Bivona and his team showed that the growth of multiple cancers slowed by suppressing the signalling pathway using an experimental compound...
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‘Drug cocktails’ could strengthen targeted cancer therapies
"Targeted therapies have revolutionised cancer treatment by targeting fewer components within a human cell, thereby promising better efficacy..."
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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Research into cellular signalling mechanisms may lead to new treatments
Wnt moves to specific areas of the cell membrane, interacting with a receptor known as Ror2, and inducing the formation of a cytoneme...
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IKZF1 gene could improve cancer immunotherapy
A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy...
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32,000 images of analysed CT scans released for AI development
Thousands of images have been released to encourage scientists to develop their analysis of lesions, advocating its use for the development of a new universal lesion detector...
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IgE protein may protect against skin cancer
The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings...
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Brain changes responsible for the appetite effects of cannabis identified
New research on how cannabis use alters eating behaviour could lead to treatments for appetite loss in chronic illness...
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Urine tests are important in diagnosing myeloma
It may be better to examine the urine and the blood of patients suspected of tumours of the plasma cells...