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Scientists discover new clue for platelet activation to target thrombosis
Researchers have revealed a novel mechanism for platelet activation, suggesting a potential target for antithrombotic therapy.
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Cardiovascular disease
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3D bioprinted blood vessel grown by Texas A&M engineers
A newly developed blood vessel model can mimic the states of health and disease, paving the way for cardiovascular drug advancements.
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Role of macrophages in blood flow regulation after tissue damage revealed
Researchers have shown in mice that macrophages play a role in controlling blood flow and healing following tissue damage.
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Drugs with potential to stop plaque build-up in arteries identified
A new compound can inhibit the build-up of plaque in arteries and prevent atherosclerosis, researchers have shown.
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Biosynthetic polysaccharide-based drugs and nutraceuticals from non-animal sources
Glycosaminoglycans (GAGs) are a class of naturally occurring polysaccharides that play vital roles in cellular functions. GAGs (eg, hyaluronic acid, heparosan, chondroitin, chondroitin sulfate, heparan sulfate and heparin) have also been utilised in biopharmaceutical and nutraceutical industries. Animal-sourced GAGs can contain process impurities and contaminants, which may result in adverse…
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New insight to guide discovery of drugs targeting ion channels
The study shows how drug-like small molecules inhibit the activity of Transient Receptor Potential Canonical 1/4/5 (TRPC1/4/5) channels and could transform the development of future therapies.
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Mutated PCSK9 gene protects against liver damage and cardiovascular disease, say researchers
Scientists suggest the PCSK9Q152H gene variant may act as a “fountain of youth”, allowing people to live longer, healthier lives.
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Safer and more affordable medicine for all? How pharmacogenomics may level the playing field
Dr Mike Tocci discusses how pharmacogenomics can revolutionise medical research and improve the efficacy and quality of drugs.
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Novel nanoparticles improve CRISPR gene editing
A study has used new synthetic lipids to deliver CRISPR gene editing tools into cells with up to 90 percent efficiency.
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Job cuts limit cardiovascular and diabetes research and development
Pharmaceutical company, Sanofi, will eliminate jobs in France and Germany and end new in-house cardiology research programmes.
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New drugs targeting gut microbes may reduce the risk of cardiovascular disease
The new class of drugs are mechanism-based inhibitors which potentially interrupt the gut microbial pathway that produces TMAO...
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Study provides insight into blood signatures of inflammation
A new study has identified a pattern of inflammation associated with cardio-metabolic risks...
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STEEL gene senses inadequate blood flow in microscopic blood vessels
A new study has found that a newly discovered gene helps grow blood vessels when it senses inadequate blood flow to tissues...
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Gut bacteria linked to age-related conditions
Study suggests that chronic inflammation in the elderly -- thought to be involved in many age-related diseases -- is due to imbalances in gut bacteria...
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Mitochondrial DNA could predict risk for sudden cardiac death
New studies add to evidence of link between mitochondrial DNA copy number and risk for cardiovascular disease...