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Chronic kidney disease

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Humanised mouse model identifies the best match for organ donor

11 January 2023 | By Izzy Wood (Drug Target Review)

US researchers have developed a mouse model that holds promise in identifying the best organ donor and showing early signs of transplant rejection.

news

China approves IND application for Everest Medicines novel BTK inhibitor

18 October 2022 | By Victoria Rees (Drug Target Review)

The Chinese National Medical Products Administration has approved a Phase Ib study of Everest Medicines' EVER001, for potential treatment of glomerular diseases.

news

Pathway and enzyme responsible for CKD thrombosis identified

2 November 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered a novel pathway and enzyme that causes thrombosis in chronic kidney disease (CKD) patients, indicating a new drug target.

Biologic to treat obesity-related diseases

news

New synthetic biologic could treat obesity-related diseases

19 May 2021 | By Victoria Rees (Drug Target Review)

A synthetically made glycopeptide biologic has shown promise as a treatment for obesity-related diseases in mice.

news

Lipid droplets may prevent kidney damage from high-fat diets

17 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown in fruit flies that lipid droplets could prevent the kidney damage that leads to chronic kidney disease.

news

Silicon-based agent could prevent progression of kidney disease and Parkinson’s

19 June 2020 | By Victoria Rees (Drug Target Review)

Japanese researchers have shown that a silicon-based antioxidant agent can suppress the development of kidney failure and Parkinson's disease in rodent models.

article

Uniting humans and data: the role of AI in genomics

27 August 2019 | By Victoria Rees (Drug Target Review)

AI has applications in many areas of research, including genomics. Slavé Petrovski of AstraZeneca reveals how AI is used in the study of the human genome and how it may evolve in the future.

article

Beyond the phenotype: using AI to better understand disease

19 August 2019 | By Victoria Rees (Drug Target Review)

Claus Bendtsen at AstraZeneca reveals how AI can be used to improve our understanding of disease, to help identify the causes of conditions and aid in drug discovery.

news

Study reveals 35 genes linked to chronic kidney disease

23 November 2018 | By Drug Target Review

A study conducted by researchers at The University of Manchester and Manchester Children's Hospital has revealed 35 genes linked to chronic kidney disease...

news

Targets for chronic kidney disease treatment

2 October 2018 | By Iqra Farooq (Drug Target Review)

The DAB2 pathway could be a crucial target in treating CKD, as mouse models show a decrease in DAB2 leads to prevention of the condition...

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Chronic kidney disease