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Using immunotherapy to prevent cancer metastases
Scientists have demonstrated how killer T cells used in immunotherapy to eliminate cancer cells can also destroy tumour lymphatic vessels, thus greatly reducing the risk of metastasis.
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Colorectal cancer
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CRISPR screens and novel drug targets
According to a new study, a metabolic enzyme studied in cancer biology is key for T-cell function, offering a novel target for anti-inflammatory therapeutics. Dr Jeffrey Rathmell and Ayaka Sugiura from Vanderbilt University in the US discuss their study with Drug Target Review and why inhibiting or genetically deleting the…
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Scientists uncover answer to colorectal cancer immunotherapy resistance
Boosting dendritic cells prevented immunotherapy resistance in mouse models, suggesting a new approach to colorectal cancer therapies.
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Small molecule RGX-202 prevents metastasis in colorectal cancer
RGX-202 was found to foil a key pathway that cancer cells rely on for energy in mice, presenting a possible new colorectal cancer therapy.
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New nanotechnology could combat colorectal cancer and melanoma
A nanotherapeutic delivery system displayed high efficacy against metastatic tumours in mice, potentially improving chemotherapy treatments.
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Computational method developed to map chromosome folding in 3D
Researchers created their new method to analyse chromosomes in 3D, revealing how misconfigurations play a role in cancer.
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Compound that targets BRAT1 protein could be used to kill cancer cells
Having synthesised the curcusone D compound, researchers demonstrated its promise as the first BRAT1 inhibitor, making it a potential cancer therapy.
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Altering balance of fibroblasts could prevent spread of colorectal cancer
Researchers have found that colorectal cancer-associated fibroblasts can be altered using a gremlin 1-neutralising antibody or by overexpressing meflin.
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AI advancing drug discovery: the future is multi-cellular studies
Drs Sam Cooper and Michael Briskin of Phenomic AI, discuss how artificial intelligence (AI) is enabling them to target multi-cellular interactions, such as those in the tumour stroma, for drug development.
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Importin-11 identified as new therapeutic target for colorectal cancer
Researchers have discovered that Importin-11, a cell nucleus import protein, is required for colorectal cancer growth and may be a possible target for new therapies.
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Novel pathway to target colorectal cancer identified
Researchers have found that PGE2, a signalling molecule involved in inflammation, promotes colorectal cancer progression through a microRNA and targeting that microRNA could have therapeutic potential.
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Genomic medicine: cracking genomes to cure ‘incurable’ diseases
We are on the precipice of realising the true potential of genomics studies. Following completion of the Human Genome Project six years ago, huge strides have been made in understanding how the genome works, shedding light on disease pathogenesis and forging therapeutic efforts. In this article, Pushpanathan Muthuirulan explains how…
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Interferon pathway could provide drug target for cancers
A study has found that signals from interferons can be blocked, allowing the immune system to attack tumours which provides a potential target.
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New target for chronic inflammation in colorectal cancer
IGF-1 activated by p38 may be a therapeutic target
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CAR-T immunotherapy eliminates metastatic colorectal cancer in mice
A CAR-T-based immunotherapy successfully kills tumours and prevents metastatic growth, in final preclinical tests before human trials...