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Researchers identify three drugs that could be repurposed for COVID-19
The candidates were screened based on their similarity to hydroxychloroquine and tested for efficacy against SARS-CoV-2 in vitro.
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COVID-19 vaccine tablet significantly reduces viral load in hamsters
Hamster challenge study results suggests the oral COVID-19 vaccine induces a robust immune response, protecting the animals from infection.
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Primate model used to explore features of SARS-CoV-2 infection
The non-human primate model exhibited a COVID-19-like disease and showed how symptoms and viral activity change over the course of SARS-CoV-2 infection.
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Scientists unveil virtual reality tool for COVID-19 drug development
The tool uses interactive molecular dynamics simulations in virtual reality (iMD-VR) to allow researchers to step inside SARS-CoV-2 enzymes and visualise molecules binding to them.
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Developing nanobodies and sybodies to combat COVID-19
Three separate studies have identified nanobodies – a miniature form of antibodies found in camelid species – that can bind to the SARS-CoV-2 Spike (S) protein and neutralise the virus in cells.
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Furin cleavage motif makes SARS-CoV-2 more aggressive than other CoVs, find scientists
A specific furin cleavage motif on the SARS-CoV-2 Spike protein, not present on other coronaviruses (CoVs), could be targeted by novel COVID-19 therapies.
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Cell line development services market to grow at 13.3 percent
Reports suggest the market growth is driven by advances in biotechnology and its applications, as well as COVID-19 research.
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Researchers develop ACE2 decoy to neutralise SARS-CoV-2
Using their de novo protein design strategy, researchers engineered human angiotensin converting enzyme 2 (hACE2) protein decoys that can protect cells from SARS-CoV-2 infection.
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T cells facilitate chronic lung injury in the elderly after viral infections, finds study
After viral pneumonia in elderly mice, there is an accumulation of dysfunctional tissue-resident memory T cells in the lungs which scientists suggest may drive chronic inflammation and fibrosis.
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Children produce a different antibody response to SARS-CoV-2 infection, finds study
A new analysis reveals that the course of SARS-CoV-2 infection and the immune response it provokes is completely different in adults and children.
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D614G mutation may make SARS-CoV-2 more contagious
According to a new study, the SARS-CoV-2 virus is accumulating genetic mutations, including one called D614G which may have made it more contagious.
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Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots
According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.
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SARS-CoV-2 can disrupt the blood-brain barrier, find scientists
Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.
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SARS-CoV-2 specific antibodies persist for five months in mild cases
In a study of mild-to-moderate COVID-19 patients scientists established that the level of certain antibodies remained stable for five months.
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Lysosomes key to coronavirus shedding, finds study
Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.