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Covid-19

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SARS-CoV-2 “Mexican variant” sequence analysed by researchers

7 June 2021 | By Victoria Rees (Drug Target Review)

Analysis of one million SARS-CoV-2 genome sequences has revealed a new variant named T478K, spreading mostly in Mexico.

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RT-ddPCR assay developed to quantify regions of SARS-CoV-2 RNA

2 June 2021 | By Victoria Rees (Drug Target Review)

Scientists have created a RT-ddPCR assay to analyse both the non-coding and coding RNA regions of SARS-CoV-2.

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Novel DNA vaccine for SARS-CoV-2 effective in rodent models

1 June 2021 | By Victoria Rees (Drug Target Review)

A new DNA vaccine encoding the SARS-CoV-2 Spike protein has shown promise at protecting mice and hamsters against COVID-19.

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Cross-reactive antibody could form basis of broad coronavirus vaccine

28 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered a cross-reactive coronavirus antibody that could aid in the development of a broad-acting vaccine or treatment.

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Inhaled nanobodies effective against SARS-CoV-2 in hamsters

27 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that inhalable nanobodies at ultra-low doses can effectively neutralise SARS-CoV-2 in hamsters.

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SARS-CoV-2 RNA analysis reveals potential treatment targets

26 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.

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WHO and Switzerland launch BioHub for pathogen storage and analysis

25 May 2021 | By Victoria Rees (Drug Target Review)

The WHO and Swiss Confederation are set to launch a BioHub Facility, intended to facilitate the sharing of pathogens globally.

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GRP78 molecular chaperone revealed as drug target for COVID-19

25 May 2021 | By Victoria Rees (Drug Target Review)

Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.

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Potential SARS-CoV-2 antiviral to be tested in human lung cells

24 May 2021 | By Victoria Rees (Drug Target Review)

A synthetic antiviral named R327 has shown promise in initial tests against SARS-CoV-2 and is now advancing to the next stage of in vitro studies.

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Computational modelling reveals SARS-CoV-2 mutation ‘hotspots’

20 May 2021 | By Victoria Rees (Drug Target Review)

A new modelling method could be used as a surveillance tool to monitor emerging infectious SARS-CoV-2 variants, scientists say.

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Potential COVID-19 antiviral formulated with siRNA-nanoparticles

19 May 2021 | By Victoria Rees (Drug Target Review)

Scientists have created an antiviral therapy using lipid nanoparticles that deliver siRNA to the lungs to treat COVID-19 in mice.

news

Microfluidic screening reveals SARS-CoV-2 antibody candidate

17 May 2021 | By Victoria Rees (Drug Target Review)

Microfluidic screening technologies have been used to discover a promising antibody candidate against SARS-CoV-2 and the South African variant.

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Researchers reveal frameshifting as SARS-CoV-2 drug target

14 May 2021 | By Victoria Rees (Drug Target Review)

A critical stage of the SARS-CoV-2 replication process, known as frameshifting, could be targeted by new drugs, researchers say.

news

Automated method to produce synthetic DNA created

13 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a technique to synthetically produce DNA oligonucleotides that avoids the degradation of phosphoramidites.

news

New vaccine protects against COVID-19 and variants in pre-clinical studies

11 May 2021 | By Victoria Rees (Drug Target Review)

A new vaccine has shown promise at protecting monkeys and mice from COVID-19, its variants and other coronaviruses.

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Covid-19