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Functioning lung cell assay for modelling COVID-19 infections developed
A UK company has announced that their lung epithelium model can successfully be used to test potential treatments for COVID-19.
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PLpro inhibitors support immune response to COVID-19 in cell cultures
Researchers have found that using GRL-0617, an PLpro inhibitor, in cell cultures blocked SARS-CoV-2 production and supported the cell immune response.
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Team suggest bradykinin system could be targeted by COVID-19 drugs
Researchers say computational analyses suggest the bradykinin system may explain some of the symptoms of COVID-19, providing a drug target.
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LY6E identified as potential immunoprotein against SARS-CoV-2
A study has demonstrated that the LY6E protein inhibits SARS-CoV-2 infection in human cell cultures, so a drug mimicking it could be a therapy for COVID-19.
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High-throughput screening reveals 21 drugs with activity against COVID-19
After screening 12,000 existing drugs, scientists have identified 21 which prevent the replication of SARS-CoV-2 in concentrations safe for patients.
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Seaweed extract outperforms remdesivir as COVID-19 therapy in vitro
According to new research, sulfated polysaccharides extracted from seaweed were more effective at inhibiting SARS-CoV-2 infection in mammalian cells than remdesivir.
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Team redesigns COVID-19 Spike protein for more stable vaccines
Researchers have modified the COVID-19 Spike protein for use in vaccines, which produces up to 10 times more protein than that of an earlier synthetic versions.
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Chloroquine does not prevent SARS-CoV-2 infection in human lung cells, study finds
A new study has shown that while chloroquine protects African green monkey kidney cells from SARS-CoV-2 infection, it does not protect human lung cells.
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Researchers develop potential drug to prevent heart attacks
A novel drug has been created which prevented the blood clotting associated with heart attacks and strokes in pre-clinical studies.
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Nanoparticle COVID-19 vaccine elicits immune response in pre-clinical studies
The vaccine candidate repRNA-CoV2S elicited both antibody and T cell responses after just two injections in mice and macaques.
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Could the Nsp1 protein be a novel drug target for COVID-19?
A study of the SARS-CoV-2 nonstructural protein 1 (Nsp1) showed it can supress translation and inhibit anti-viral defence mechanisms, making it a potential target for drugs.
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CBD may combat cytokine storms and respiratory distress caused by COVID-19
Scientists found in a murine model of acute respiratory distress syndrome (ARDS) that cannabidiol (CBD) helped the lungs recover from excessive inflammation caused by COVID-19.
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Interferon deficiency and heightened inflammation are hallmarks of severe COVID-19, say researchers
The newly identified hallmarks of critical COVID-19 indicate a combination of interferon supplementation and anti-inflammatory therapies could be effective in treating patients with severe COVID-19 symptoms.
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Most antibodies targeting SARS-CoV-2 use specific immunoglobulin subtype
Researchers reveal IgHV3-53 is the most common immunoglobulin mutation used to target the receptor binding domain on the SARS-CoV-2 spike protein.
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Pre-clinical study supports remdesivir as COVID-19 treatment
Scientists demonstrated that remdesivir can inhibit SARS-CoV-2 replication in human lung cells and improve lung function in mice with COVID-19.