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Covid-19

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Nanobodies developed to image COVID-19 Spike protein

20 April 2020 | By Victoria Rees (Drug Target Review)

Researchers in the UK have selected nanobodies that bind with high affinity to the Spike protein on the COVID-19 coronavirus, enabling stabilisation for imaging.

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UK government funds 21 new research projects into COVID-19

20 April 2020 | By Victoria Rees (Drug Target Review)

A total of 21 COVID-19 research projects have been granted funding by the UK government, including vaccine and therapeutic development.

RNA strand in light blue surrounded by coronavirus particles in darker blue

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Novel visualisation platform to aid understanding of COVID-19 strain evolution

20 April 2020 | By Hannah Balfour (Drug Target Review)

The visualisation platform is being used to analyse how the SARS-CoV-2 virus causing COVID-19 is evolving and could be used to inform drug design.

head and shoulders photo of an adult cynomolgus macaque

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Cynomolgus macaques: a promising animal model of COVID-19 infection?

17 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers comparing the effects of SARS-CoV-2, SARS-CoV and MERS-CoV in cynomolgus macaques suggest they could be an effective animal model for testing COVID-19 therapeutics.

tablets, capsules and a laboratory scientist in a white coat on a swirling blue background

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Screening 10,000 compounds identifies six potential COVID-19 therapeutics

17 April 2020 | By Hannah Balfour (Drug Target Review)

High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.

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Specialised proteins could halt cytokine storms in COVID-19 patients

17 April 2020 | By Victoria Rees (Drug Target Review)

Researchers who developed modified proteins say this could be used in the fight against COVID-19, by tackling cytokine storms.

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Severe COVID-19 symptoms may be caused by overactive neutrophils

16 April 2020 | By Hannah Balfour (Drug Target Review)

An international consortium suggest that the severe symptoms of COVID-19, including Acute Respiratory Distress Syndrome (ARDS), could be caused by Neutrophil Extracellular Traps (NETs).

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Celltrion selects 14 lead monoclonal antibodies for COVID-19 treatment

16 April 2020 | By Victoria Rees (Drug Target Review)

After screening 300 antibodies, Celltrion has identified the 14 most powerful that could potentially combat the COVID-19 coronavirus.

article

The coronavirus as a personalised enemy of mankind

15 April 2020 | By Dr Ulrich Kutschera (University of Kassel)

How has evolution led us to the point where humans are an ideal host for SARS-CoV-2, the virus that causes the COVID-19 coronavirus?

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Researchers reveal how remdesivir prevents COVID-19 viral replication

15 April 2020 | By Victoria Rees (Drug Target Review)

According to a new study, the drug remdesivir is a very potent inhibitor for coronavirus polymerases - demonstrating its potential for combatting COVID-19.

drug capsule repelling coronavirus particles

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COVID-19 Drug Repurposing Database made open-access by Excelra

15 April 2020 | By Hannah Balfour (Drug Target Review)

The enterprise revealed that it has made its COVID-19 Drug Repurposing Database open-access to aid in the search for an effective therapeutic.

stages of plant growth from small shoot on the left to larger leafed plant on the right

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Plant bio-factories contributing to the COVID-19 fight

15 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers have made the genome of the Nicotiana benthamiana plant, a commonly used bio-factory organism, public to aid in COVID-19 vaccine production.

Cartoon of people of various races/religions/ethnicities all wearing white surgical masks to protect against COVID-19

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Researchers release 21 openly available SARS-CoV-2 genome sequences

14 April 2020 | By Hannah Balfour (Drug Target Review)

Austrian researchers reveal the first 21 SARS-CoV-2 viral genomes as part of their project to aid in international understanding of how the virus causing COVID-19 mutates.

news

Main COVID-19 protease revealed, enabling screening of potential drugs

14 April 2020 | By Victoria Rees (Drug Target Review)

Chinese researchers who determined the crystal structure of the COVID-19 protease Mpro used this information to screen over 10,000 compounds to combat the coronavirus.

Mesenchymal stem cells as COVID-19 therapy

article

Mesenchymal stem cells secretome as a prospective therapeutic option for COVID-19 patients

13 April 2020 | By Avinash Kharat (Dr D Y Patil Vidyapeeth), Avinash Sanap ( Dr D Y Patil Vidyapeeth), Dr Ramesh Bhonde (Dr D Y Patil Vidyapeeth), Supriya Kheur (Dr D Y Patil Vidyapeeth)

Researchers propose using mesenchymal stem cells to counter the pro-inflammatory cytokines associated with COVID-19 coronavirus symptoms.

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