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Although many potential targets have been identified for Alzheimer’s disease (AD), there is no effective treatment for this debilitating condition. In this article, Monika Schmidt and Sheraz Gul delve into the key proteins implicated in AD and suggest how phenotypic assays could aid in AD drug discovery.
Scientists have designed a high affinity antibody for pathogenic amyloid beta oligomers, a key driver of Alzheimer’s disease, for use in further research and as a potential diagnostic tool.
Scientists used optical photothermal spectroscopy (O-PTIR) to image murine neurons affected by early stage Alzheimer’s disease, providing insight into the progression of the disease.
Research identified a small molecule that targets the mRNA of α-synuclein and prevents the formation of the protein, an approach which could provide novel neurodegeneration therapies.
Researchers have created a new combination vaccine therapy that can induce strong immune responses against tau and Aβ pathologies seen in Alzheimer’s in bigenic mice.
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
A study has discovered the regulating process behind cell autophagy which could aid in the development of neurodegenerative disease treatments.
A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.
New research has identified an enzyme which causes degradation of dendritic spines, pointing to a drug target for Alzheimer’s.
Nanoscientists have identified genes that link to dementia, in the hope that future therapies could target these genes for positive results in patients...
Researchers at the University of San Francisco have suggested how advances in EEG brain scanners could help to diagnose brain conditions earlier...
A team of neuropathologists worked together to show that the impairments affecting mitochondria also affect neighbouring organelles...
Early-stage research has uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people...
A new fibre-based endoscope, tested in mice, poised to bring new insights into brain function...
A new study which identifies how acetylcholine impacts learning and memory by acting at different receptors could prove significant in the drive to develop more targeted and effective therapies for dementia...
