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Induced pluripotent stem cells and CRISPR reversed diabetes in mice
Induced pluripotent stem cells made to produce insulin and CRISPR, used to correct a genetic defect, cured Wolfram syndrome in mice.
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Diabetes
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Predicting which diabetes treatments will reach clinical trials
Researchers at MIT have developed a mathematical model that can calculate whether diabetes treatments in pre-clinical trials will be successful in humans.
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The latest developments in diabetes drug discovery
Several new advances have been made in the field of drug discovery for diabetes – here, three of the most recent have been rounded up.
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Study shows how skin cells change when preparing to heal wounds
The researchers hope their study into how cellular heterogeneity changes as the skin heals wounds will allow further research into pathological conditions that cause poor wound healing.
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Ion channel ball-and-chain mechanism imaged after decades of attempts
Scientists have imaged the ball-and-chain mechanism using cryogenic electron microscopy and hope their work could be applied in the design of novel therapeutics.
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Structure of lipin enzyme responsible for triglycerides revealed for first time
Researchers have obtained the crystal structure of the lipin enzyme, the regulator of triglyceride production, which they say could inform research into heart disease, obesity and diabetes.
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Novel label-free method enables imaging of metabolites
A label-free imaging technology has been developed by researchers, allowing them to investigate biomolecules such as metabolites, aiding in the study of drugs.
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G-1 compound could be used to fight obesity and diabetes
Studies in mice have shown that the G-1 compound reduces obesity and the effects of diabetes by burning extra calories, report researchers.
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Molecular ‘switch’ could help treat or reverse age-related diseases
A molecular 'switch' that controls the immune machinery responsible for chronic inflammation has been identified which could help treat or even reverse the development of age-related conditions like Alzheimer's, Parkinson's, cancer and diabetes.
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NLRP3 inflammasome ‘off switch’ reverses effects of chronic inflammation
Research into age-related chronic inflammatory disorders has identified an ‘off switch’ on the NLRP3 inflammasome that could be targeted in new therapies.
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Inflammatory molecules for controlling capillary loss discovered
Scientists have discovered three major pro-inflammatory mediators that drive capillary loss and identified drug combinations to prevent the degeneration of these tiny blood vessels.
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The growing possibilities for stem cells in pharma
Drug Target Review explores the latest applications of stem cells in modelling disease, drug production and the most recent steps in regenerative medicine provided by research.
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New drug prevents liver damage, obesity and glucose intolerance in mice
Mice given a novel drug that targets a key gene involved in lipid and glucose metabolism were able to tolerate a high-fat diet regimen without developing significant liver damage.
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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
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New insights into major disease pathways made with protein discovery
A new chemical tool has been used to identify hundreds of modified proteins which allows new insights to major diseases.