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Ebola virus

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Uncovering the first FDA-approved drug for Ebola virus infection

6 February 2023 | By Izzy Wood (Drug Target Review)

US scientists have outlined the structure and function of the first FDA approved drug for the Ebola virus.

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Assessing compound activity to accelerate drug discovery

22 June 2021 | By Victoria Rees (Drug Target Review)

In this article, Drug Target Review’s Victoria Rees explores a new screening platform that assesses the biological activity of molecules to identify potential drugs. Using their new technique, researchers from the US National Institutes of Health (NIH) identified potential COVID-19 therapeutics.

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GRP78 molecular chaperone revealed as drug target for COVID-19

25 May 2021 | By Victoria Rees (Drug Target Review)

Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.

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Microtitration assay developed to detect Ebola virus in vitro

24 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have successfully created an unbiased, high-throughput microtitration assay for the quantification of Ebola virus in cell lines.

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New vaccine design developed to protect against Ebola virus

13 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have designed a new nanoparticle-based vaccine against Ebola that has shown promise in mice and rabbits.

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SARS-CoV-2 variants: the role of sequencing and vaccine development

22 March 2021 | By Victoria Rees (Drug Target Review)

Professor Martin Michaelis and Dr Mark Wass explain why new SARS-CoV-2 variants are emerging around the world and how vaccines will have to adapt in response.

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Screening by compound activity could accelerate drug discovery

2 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a new screening technique called biological activity-based modelling to identify drug candidates.

A coiling protein 'shell,' called a nucleocapsid, shown here, surrounds Ebola's genetic material, which consists of single-strand RNA. University of Delaware researchers are simulating the way molecules of this nucleocapsid move and interact, atom by atom, to understand their functions and expose targets for anti-viral treatments [Credit: Juan Perilla Laboratory].

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The nucleocapsid as a novel drug target for Ebola virus

22 October 2020 | By Hannah Balfour (Drug Target Review)

Using supercomputer stimulations researchers reveal that the structural stability of the Ebola nucleocapsid is depended on the presence of RNA and interactions with charged ions.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

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Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

person in white coat holding back or seperating pathogen walls on wither side of them

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NIAID unveils new Centers for Research in Emerging Infectious Diseases (CREID)

2 September 2020 | By Hannah Balfour (Drug Target Review)

The global network of centers will investigate where pathogens emerge and how they adapt to cause disease in humans, in the hopes of increasing our preparedness for future disease outbreaks.

shiled fending off coronavirus particles

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Novel protection pathway makes cells resistant to Ebola and coronavirus infection, report scientists

28 August 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal that activating the MHC class II transactivator (CIITA) and CD74 genes protected cells against infection by Ebola and SARS-CoV-2.

long thin filament-like viral particle in brown with blue surface glycoproteins that look like polka dots

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Experiments with Marburg virus reveal novel antibody protective mechanisms

22 April 2020 | By Hannah Balfour (Drug Target Review)

Researchers discovered the monoclonal antibodies of a convalescent Marburg infection patient bound to the glycoprotein and combatted infection in two novel ways.

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Using Ebola’s immune evasion mechanism to target glioblastoma

13 February 2020 | By Hannah Balfour (Drug Target Review)

An innovative chimeric vaccine containing an Ebola gene that helps the virus evade the immune system has been used to selectively target and kill glioblastoma in mice.

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Two-antibody cocktail could treat Ebola in one dose

10 January 2019 | By Drug Target Review

A study has described a two-antibody cocktail medication that has been successful in vivo italics trials and could treat Ebola in one dose...

news

Ebola-fighting protein found in the human body

13 December 2018 | By Drug Target Review

A study has found that the human protein, RBBP6, helps fight Ebola virus by interfering with the virus replication cycle…

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Ebola virus