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New therapy stops seizures in mouse model of rare childhood epilepsy
A rare form of childhood epilepsy could be improved with a therapy called antisense oligonucleotide, following the development of a new model.
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Epilepsy
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Interaction site for serotonin type 3A and RIC-3 chaperone identified
To address the receptor dysfunction associated with several neurological diseases, scientists have provided novel insights into a protein-protein interaction that could lead to more effective treatments.
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Novel small molecule could treat Alzheimer’s disease and Dravet syndrome
A new experimental drug was shown by researchers to restore natural brain rhythms in mouse models of Alzheimer’s and promote learning and memory.
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Transitioning novel peptide hits into lead compounds
Unlike synthetic compound libraries, natural product hits must be identified and characterised, as the molecule is often unknown. Venom peptides are often inherently stable due to cysteine knots whereas other peptides may not be. Steve and Carol Trim discuss the challenges of the hit-to-lead journey with these non-standard hits.
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Membrane protein function behind epilepsy discovered
Researchers have revealed the 3D structure of a membrane protein which plays a role in the development of conditions such as epilepsy and blindness.
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Treatment for Lafora disease shows promise in pre-clinical study
A novel antibody-enzyme fusion therapeutic strategy for Lafora disease has shown effectiveness in pre-clinical study mice models.
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Brain-heart link points at potential biomarker for trauma-induced epilepsy
Scientists at Penn State find that heartbeat irregularities connected to brain activity abnormalities may pave the way to predict onset of epilepsy in certain patients…
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How cannabis and cannabis-based drugs can harm your brain
Long-term use of either cannabis or cannabis-based drugs impairs memory...
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Researchers develop a new method to discover drugs to treat epilepsy
Method uncovers a promising new use for a well-known cancer drug in stopping difficult-to-treat seizures...
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Chemogenetics provides hope for severe epilepsy
Researchers believe that they have found a method that in the future could help people suffering from epilepsy so severe that all current treatment is ineffective...
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New study directly links mossy brain cell activity to epilepsy symptoms
New findings from an NIH-funded study of mice suggest that loss of mossy cells may contribute to seizures and memory problems in a form of epilepsy.
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Specific set of nerve cells controls seizures’ spread through brain
Experimental activation of a small set of nerve cells in the brain prevents convulsive seizures in a mouse model of temporal lobe epilepsy.
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Genetic testing may detect childhood epilepsy
Specific genetic factors have been found to be the cause of epilepsy in 40 percent of patients evaluated with seizures...
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Micro-gene protects the brain from developing epilepsy
A tiny microRNA has been shown to play a beneficial role in protecting the brain from epileptic seizures in specially engineered transgenic mice.
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New targeted approach for epilepsy drug therapies
New research from the University of Liverpool, in collaboration with the Mario Negri Institute in Milan, has identified a protein that could help patients with epilepsy respond more positively to drug therapies.