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Enhancing drug discovery using genetically diverse mouse models
Researchers suggest that integrating genetically diverse mouse models with cell-based assays will better replicate human diseases.
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Heart disease
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Restoring TERT to attenuate ageing hallmarks
In this Q&A, Dr Ronald DePinho of MD Anderson elucidates their preclinical proof-of-concept that adjusting TERT levels could be a viable therapeutic approach for mitigating age-related diseases, such as cancer, heart disease and Alzheimer’s.
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Discovery of over 100 genomic loci linked to hypertension
The study’s findings explain the genetic differences in people’s blood pressure, which could lead to personalised medicine approaches.
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4PY found to directly trigger vascular inflammation
Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.
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Essential role of Nrg1 in heart development
New research identifies how trabeculae transform into ventricles, which could positively impact heart disease treatments.
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Investigating heart disease through arterial calcification and repair mechanisms
Professor at Texas Tech University's Department of Biological Sciences has been granted an Innovative Project Award by the American Heart Association to delve into the intricacies of atherosclerosis, a condition responsible for artery thickening and severe health complications.
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Step forward in gene therapy to treat cause of sudden cardiac arrest
Using gene therapy, the researchers corrected abnormal heart rhythms by restoring a protein that heart cells need to establish connections with one another.
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New therapeutic strategy could reduce cardiovascular disease in cancer survivors
US researchers have discovered that cancer treatments or anthracycline drugs, cause cardiovascular disease by activating a key inflammatory signalling pathway.
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New target in the fight against heart disease
US scientists have new insight into how heart cells enable unhealthy growth, and identify a new target to intervene against heart disease.
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New findings may lead to cardiovascular disease treatment
New research has found that immune cells produce a chemical messenger that prevents heart disease–related inflammation
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Targeting PEG2 reverses age-related cognitive decline in mice
The discovery of an inflammatory pathway promoting brain ageing and cognitive decline could lead to new treatments for age-related conditions.
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Structure of lipin enzyme responsible for triglycerides revealed for first time
Researchers have obtained the crystal structure of the lipin enzyme, the regulator of triglyceride production, which they say could inform research into heart disease, obesity and diabetes.
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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CAR T-cell therapy could be harnessed to treat heart disease
New study finds immunotherapy reduces cardiac fibrosis and restores heart function in mice after cardiac injury.
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RNA-seq of 20,000 cardiac cells reveals heart disease insights
RNA analysis of 20,000 cardiac cells from heart tissue in both ordinary and deceased mice showed an insight to the development of heart disease...