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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
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HIV
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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Method to coax immune system into selecting HIV antibodies developed
Immunogens can be used to coax the immune system into producing broadly neutralising antibodies to fight a HIV infection, making a vaccine against the condition more likely, say researchers.
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Newly engineered peptide shows long-acting efficacy against HIV
Researchers have developed a novel peptide with a prolonged half-life that has demonstrated success in rhesus monkeys and mice for inhibiting HIV infections.
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Experimental HIV vaccine induces bnAb production in models
Researchers have developed a vaccine for HIV that has shown success in rabbits, by neutralising a wide range of HIV strains using bnAbs.
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Better HIV, lupus and hep C treatments possible with malaria discovery
A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.
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Modified CRISPR gene editing tool could improve therapies
New cell experiments show more effective genetic 'cuts' that could one day become the foundation of more effective gene therapies.
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New HIV vaccine candidate design developed by researchers
A study has demonstrated a novel vaccine design in mice which could be used to immunise patients against HIV.
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Hitting the target – utilising recombinant antibodies for viral research
Having worked in antibody research for over 20 years, Gary McLean has seen how the industry has progressed and understands the potential that antibodies have in the future of medicine. Nikki Withers hears how the focus has shifted from discovery to genetic sequence manipulation and how this can be applied…
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HIV infant model opens new avenues for research
An animal model to test HIV infection in infants could lead to biomarkers that predict viral rebound after ART interruption.
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‘Reverse vaccinology’ used to create novel HIV treatment
Researchers have developed a new HIV vaccine which has shown success in monkeys in pre-clinical trial studies.
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New version of HIV vaccine could soon be ready for clinical trials
A promising vaccine that clears an HIV-like virus from monkeys is closer to clinical trial human testing.
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Potential cure for HIV revealed through combined therapies
A new study has used combined therapies to eliminate HIV from mice models, providing potential future cures.
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‘CRISPR babies’ may have shorter life expectancy
A study of almost half a million people links a mutation that protects against HIV infection to an earlier death.
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Custom-made proteins create antibodies to fight HIV
Computational modelling has been used to design proteins that mimic the conserved protein surface of different strains of HIV for use in vaccines...