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Mini-colons offer improved cellular diversity, longevity and function
Mini-colons, which closely resemble in vivo tissue, were used for several applications, including the characterisation of anticancer drug toxicity profiles.
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inflammatory bowel disease
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Exploring the role of class IIa HDACs in inflammatory diseases
The pharmacological inhibition of class IIa HDACs could be a therapeutic approach for addressing Th17-related inflammatory and autoimmune diseases.
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Researchers discover the role of intestinal fibrosis in inflammatory bowel disease
The scientists used a new in vitro platform, which allowed intestinal organoids to be cultured on an open lumen, planar system that could be manipulated experimentally.
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Tregs produced by mesenchymal stromal cells with novel technique
By culturing blood cells with mesenchymal stromal cells (MSCs), researchers induced the production of cells with the same functionality as Tregs.
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Research identifies cells which contribute to inflammatory diseases
A new study has shown that there are two populations of cells in the gut which leads to drug development potential.
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Gut microbiome identified as cause of IBD, study finds
A study has detailed the change in the gut microbiome, increasing the potential for new IBD therapies.
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Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Genetic model predicts risk for common deadly diseases
Using data collected from the UK, the data suggests that up to 25 million people in the US may be at more than triple the risk of coronary artery disease...
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EBV protein can ‘switch on’ risk genes for autoimmune diseases
EBV may trigger some cases of lupus, say NIH-supported researchers...
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Scientists discover promising off-switch for inflammation
Scientists have discovered that itaconate - a molecule derived from glucose - acts as a powerful off-switch for macrophages...