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Slc4a4 restores normal brain function after ischemic stroke
Researchers have elucidated how Slc4a4 governs astrocyte-endothelial cell interaction in blood-brain barrier maintenance and repair.
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Ischemic stroke
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Enhancing the collateral network for beneficial reperfusion
Future interventions for ischaemic stroke patients should enhance collateral function to reduce brain haemorrhage and mortality.
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X-ray irradiation reversed motor deficits after brain injury
Low dose ionising radiation reduced lesion size and reversed motor deficits in traumatic brain injury and ischemic stroke mice.
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Potential pathway to improved stroke recovery
Japanese researchers identify a protein that reduces inflammation, stimulates neural growth, and improves sensory and motor functions following ischemic stroke in mice.
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Neurolysin shown to be potential drug target for ischemic stroke
Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.
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Gene therapy method could restore visual function after stroke
Scientists have revealed a way to use gene therapy to turn glial brain cells into neurons, restoring vision and potentially restoring motor function.
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IAIPs shown to reduce ischemic stroke damage in pre-clinical study
Inter-alpha inhibitor proteins (IAIP) demonstrated efficiency in reducing damage from an ischemic stroke, reveals pre-clinical study.
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New mRNA delivery system effectively protects neurons in rats from ischemia
Researchers have shown that an mRNA delivery system can be used to produce the BDNF protein in rats to protect neurons from ischemia.
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Team modifies therapeutic molecule to improve stroke treatment
Researchers have shown that adding a polymer to glutamate-oxaloacetate transaminase means the molecule can treat stroke for up to six days in rats.
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Novel antiplatelet drug is effective at treating heart attacks in mice, say researchers
The novel nanoparticle delivered Mp6 peptide was able to inhibit thrombosis and reduce inflammation without increasing the risk of bleeding in mice after heart attacks.
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Novel complement inhibitor improves ischemic stroke recovery in mice, say researchers
Administering a novel complement protein blocker (B4Crry) alongside reperfusion therapy improved cognitive and motor recovery in a model of ischemic stroke.
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B cells may travel to remote areas of the brain to improve stroke recovery
Research has found that after stroke in mice, B cells migrate to far regions of the brain that control motor functions, indicating their role in recovery.
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Retinoid X receptor could be targeted to improve recovery from stroke
Scientists conducted a pre-clinical trial in mice and showed that activating the retinoid X receptor (RXR) enhances the activity of phagocytic immune cells and aids recovery from stroke.
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PSD-95 molecule reveal potential treatment for stroke patients
A novel hybrid approach has revealed a 3D structure of a protein fragment that could serve as a drug target in treating stroke patients...
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New study proves e-ASPECTS could predict benefit of mechanical thrombectomy
A new study shows e-ASPECTS correlates with and is a predictor of outcome after mechanical thrombectomy. With mechanical thrombectomy gaining ground as a possible treatment for patients suffering from acute ischemic stroke, it is even more important to select those patients who can derive the most benefit.