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Study identifies molecule key in leukaemia treatment resistance
Researchers have found a molecule, which when deleted, increases leukaemia sensitivity to natural killer cells and is a drug target.
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Leukaemia
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New model found to improve drug development in pre-clinical trials
Researchers have successfully created a multi-organ in vitro model to test toxicity and efficacy of drugs.
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Rare mechanism for ALL to relapse after CAR-T therapy
A single leukemic cell has become resistant to CAR-T therapy after unknowingly engineered with the leukemia-targeting CAR lentivirus...
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Promising drug targets for t-cell lymphoblastic leukaemia
Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...
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Researchers uncover up to 100 potential drug targets for cancer
In a new study based on mouse cells, researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.
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Leukaemia protective role of Y chromosome gene discovered
Scientists have discovered the first leukaemia protective gene that is specific to the male-only Y chromosome...
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UFD1 protein responsible for aggressive leukaemia
Researchers have identified a protein critical for the aggressiveness of T-cell leukaemia...
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IPSE protein has potential to alleviate debilitating disease
Chemotherapy-induced hemorrhagic cystitis alleviated by a protein that parasites use to keep hosts alive...
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CRISPR-based system identifies drug targets in AML
Scientists have discovered a way to rein in an overactive protein that drives some aggressive leukaemias...
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HLF gene protects blood stem cells by maintaining them in a resting state
The HLF gene is necessary for maintaining our blood stem cells in a resting state, which is crucial for ensuring normal blood production.
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Drugs targeting the cells circadian rhythm offers hope for glioblastoma
An experimental drug demonstrated selective cancer-killing ability against breast, colon, leukaemia, brain and melanoma cancer cells with no apparent effects on normal cells...
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CRISPR-engineered cancer model to test therapeutics
A new technique for modelling leukaemia may aid drug discovery...
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Antibiotic identified that reduces infection risk in young leukaemia patients
Researchers have identified an antibiotic that significantly reduced the odds of infections in children starting treatment for ALL without an apparent increase in antibiotic resistance...
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Chemo-boosting drug discovered for leukaemia
Drugs developed to treat heart and blood vessel problems could be used to treat leukaemia...
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New cancer drug tested in mice may benefit certain leukaemia patients
Almost 6,000 new cases of acute lymphoblastic leukaemia, or ALL, are expected to be diagnosed this year in the United States. The blood cancer can affect both children and adults.