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NGLY1 protein identified as potential target for melanoma treatment
Scientists in the United States have inadvertently uncovered a promising treatment for melanoma that targets the NGLY1 gene.
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Cancer immunotherapy researchers win Nobel prize
Researchers from the US and Japan have received the Nobel prize in medicine for their development of cancer immunotherapy using PD-1 and CTLA-4...
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‘Paintable’ chemotherapy for melanoma shrinks tumours
A hydrogel incorporating transfersomes and chemotherapy drugs incorporated with some intravenous medication may be the best treatment for melanoma...
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Research team develops predictor for immunotherapy response in melanoma
Researchers have developed a gene expression predictor that can indicate whether melanoma in a specific patient is likely to respond to treatment with immune checkpoint inhibitors...
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Targeting telomerase as therapeutic strategy for melanoma
Combination therapy co-targeting the mitochondria enhances the antitumour effect of telomerase inhibition in NRAS-mutant melanoma.
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Disrupting macrophage action aids melanoma immunotherapy success
Scientists in Switzerland have uncovered a potential means of increasing effective treatment of melanomas with immunotherapy, by disrupting the action of macrophages.
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Drugs targeting the cells circadian rhythm offers hope for glioblastoma
An experimental drug demonstrated selective cancer-killing ability against breast, colon, leukaemia, brain and melanoma cancer cells with no apparent effects on normal cells...
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Biomarkers identified that predict immunotherapy success
Researchers in Switzerland have identified biomarkers in the blood that can predict which patients are likely to respond favourably to immunotherapy treatment for cancer.
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Epigenetic compound inhibits the growth of melanoma cells
Researchers have developed a compound that successfully inhibits the growth of melanoma cells by targeting specific epigenetic modifying proteins...
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Novel compound restores immune response in patients with melanoma
A novel compound may restore immune response in patients with melanoma, according to a study presented at the ESMO Immuno Oncology Congress 2017.1
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GDF6 gene associated with metastatic melanoma
Researchers have revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma...
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B-cells promote melanoma progression and resistance to therapy
Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...
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Gut microbes linked to immunotherapy response in melanoma patients
7 November 2016 | By Niamh Louise Marriott, Digital Content Producer
Patients with malignant melanoma are more likely to respond to immunotherapy treatment if they had greater diversity in their gut bacteria, according to...
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MSD acquires drug discovery company IOmet
12 January 2016 | By Victoria White
The acquisition includes IOmet's comprehensive preclinical pipeline of IDO (indoleamine-2,3-dioxygenase 1), TDO (tryptophan-2,3-dioxygenase), and dual-acting IDO/TDO inhibitors...
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New class of inhibitory compounds aid melanoma treatments
3 December 2015 | By Victoria White
Using cell cultures of melanoma, researchers showed that these acid ceramidase inhibitors make melanoma cells more prone to be killed...