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New skin cell mechanism discovery could treat muscle-related diseases
Scientists have identified the mechanism behind the conversion of skin cells into immature muscle cells, which could lead to therapies preventing muscle degeneration.
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Muscular dystrophy
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New muscular dystrophy treatment shows promise in pre-clinical trials
A group of researchers has used locked nucleic acid gapmer antisense oligonucleotides to treat facioscapulohumeral muscular dystrophy in cells and mice.
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Muscle cell atlas developed to aid muscular disease and injury research
Researchers have created a new technical resource atlas which maps the 15 distinct cell types involved in muscle repair for disease and therapy research.
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Stem cell models of human spine development unveiled
Scientists have created the first lab-dish models of the cellular clock, where each 'tick' stimulates the formation of the vertebra, which uses stem cells derived from adult human tissue.
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No-cut CRISPR could be used to treat muscular dystrophy
Researchers have successfully used a no-cut CRISPR gene editing technique as a therapy for muscular dystrophy in mice models.
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SMCHD1 protein found essential to X chromosome inactivation
The structural protein is required for the chromosome to adopt a conformation that suppresses gene expression...
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Study demonstrates PLX-PAD cells are effective in treating DMD
22 June 2016 | By Victoria White, Digital Content Producer
Pluristem Therapeutics has reported positive data from preclinical studies of its PLX-PAD cells in the treatment of Duchenne muscular dystrophy...
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New target identified for muscular dystrophy
1 June 2016 | By Victoria White, Digital Content Producer
Scientists have discovered that muscle cells affected by muscular dystrophy contain high levels of an enzyme that impairs muscle repair...
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DMD engineered muscle cells offer clues to genetic variations
26 May 2016 | By Victoria White, Digital Content Producer
Researchers have found a way to make human muscle cells bearing genetic mutations from people with Duchenne muscular dystrophy (DMD)...
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Neurodegenerative diseases: The potential of cyclophilin inhibition
21 January 2016 | By Hans Fliri PhD, Chairman, Cypralis
Here, Dr Hans Fliri, Chairman and CEO of Selcia and Chairman of Cypralis, presents a strong case for targeting mitochondrial cyclophilin D to prevent progression of chronic neurodegenerative diseases...
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Dasatinib shows promise in Duchenne muscular dystrophy
6 January 2016 | By Victoria White
Researchers tested the drug, commonly used to treat leukaemia, in zebrafish bred to carry Duchenne muscular dystrophy and recorded a 40% improvement in the condition of the fish...
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Duchenne muscular dystrophy identified as a stem cell disease
17 November 2015 | By Victoria White
A new study is the first to show that Duchenne muscular dystrophy directly affects muscle stem cells...
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Exon skipping demonstrates success in severe form of muscular dystrophy
13 October 2015 | By Victoria White
An RNA editing technique called "exon skipping" has demonstrated preliminary success in treating Limb Girdle Muscular Dystrophy Type 2C in a new study...
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Acceleran presents preclinical data for muscle therapeutics ACE-083 and ACE-2494
8 October 2015 | By Victoria White
Acceleron reported the results at the 20th International Annual Congress of the World Muscle Society (WMS)...
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Summit Therapeutics publishes preclinical data on disease-modifying potential of utrophin modulation in DMD
13 July 2015 | By Victoria White
Summit Therapeutics has announced the publication of preclinical data on the disease-modifying potential of utrophin modulation in the treatment of DMD...