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Blastoids enable greater understanding of human gastrulation
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.
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neurodegeneration
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Study concludes that most aspects of aging relate to gene length
New findings about how long genes become less active with age could impact treatments for neurodegeneration, among other conditions.
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Human 3D cell-based systems to research gout: drug discovery for a neglected disease
In this article Andrew Nyborg from Horizon Therapeutics discusses why researchers are taking a second look at gout and how they are modelling the condition, which is unique to humans.
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New class of inhibitors protect mice from neurodegeneration
So called "interface inhibitors" could be used to protect against neurodegeneration, researchers have said.
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Novel alpha-synuclein structures could be the target for future Parkinson’s therapies
Researchers observed new structures of alpha-synuclein aggregates in their study exploring how the presence of cell membrane phospholipids impacts protein aggregation.
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Novel gene promoters could improve gene therapies for neurological diseases
Novel promoters based on those in the herpes viruses, enabled delivery of larger genes and increased the period they were active in the nervous system.
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New mass spec technique used to determine structure of sugars
A new method has been invented that boosts the mapping of heparan sulfates and which the researchers say could be widely used for drug discovery.
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TEX264 protein could be targeted to help protect DNA from damage
Scientists have identified that the TEX264 protein and associated enzymes protect the genome from damage, which could lead to new anti-ageing and neurodegeneration therapies.
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Microprotein revealed to regulate cell stress by study
Researchers have discovered a microprotein that acts as a regulator of cell stress, which could be used in developing therapies for a wide range of conditions.
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Genes linked to dementia identified
Nanoscientists have identified genes that link to dementia, in the hope that future therapies could target these genes for positive results in patients...
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Atg2 tethers pre-autophagosomal membranes to endoplasmic reticulum
Researchers at Tokyo University have investigated the role of the Atg2 protein in the process of autophagy to aid drug discovery into neurodegeneration...
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Nuclear tracer helps to study the aging brain
A PET nuclear tracer could help researchers to understand neurodegeneration in aging brains better, as it enters the brain and distributes quickly...