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Refreshing how we approach neuroscience with a novel screening technology
Drug Target Review discusses how NETSseq, a novel profiling technology, is bringing new insights to neurodegenerative and psychiatric diseases.
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Neurodegenerative diseases
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High-speed microscope can capture brain signals and calcium concentrations
The novel technology allows researchers to create three-dimensional images of signal propagation and calcium concentration changes in the neocortex of live mice.
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Antibodies stimulate microglia to degrade Alzheimer’s amyloid plaques
A novel antibody has been shown to stimulate microglia to degrade amyloid plaques in a murine model of Alzheimer’s disease.
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Naphthyridine-Azaquinolone reverses Huntington’s DNA repeats in mouse model
Researchers show Naphthyridine-Azaquinolone (NA) could be a possible future therapy able to slow the progression and improve the symptoms of Huntington’s disease.
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Inflammatory molecules for controlling capillary loss discovered
Scientists have discovered three major pro-inflammatory mediators that drive capillary loss and identified drug combinations to prevent the degeneration of these tiny blood vessels.
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Small molecule targeting mRNA could slow the progression of Parkinson’s disease
Research identified a small molecule that targets the mRNA of α-synuclein and prevents the formation of the protein, an approach which could provide novel neurodegeneration therapies.
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Levels of neurogenesis could be a therapeutic target in neurodegenerative disease
Research has identified that regions of the brain can regenerate via neural stem cells and the process of neurogenesis which could provide a new avenue for regenerative therapeutics.
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Novel small molecule could treat Alzheimer’s disease and Dravet syndrome
A new experimental drug was shown by researchers to restore natural brain rhythms in mouse models of Alzheimer’s and promote learning and memory.
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The implication of a dysfunctional proteasome regulator in neurodegenerative disease
Disrupted protein homeostasis from PI31 inactivation may initiate the process of neurodegeneration seen in Alzheimer’s, ALS and other similar diseases, says new research.
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Self-cannibalising mitochondria discovery may lead to ALS treatment target
A new phenomenon in the brain that could explain the development of early stages of neurodegeneration has been discovered which could lead to a future target for drug therapies for ALS.
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Salamander gene partnerships could help spinal cord regeneration
Gene partnerships found in salamander could give insights into how spinal cord injuries and neurodegenerative conditions could be better treated...
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LXB4 lipid protect neurons against glaucoma
Researchers have identified a new neuroprotective factor that has the potential to help people suffering from glaucoma...
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Antibiotics weaken Alzheimer’s disease progression
21 July 2016 | By Niamh Louise Marriott, Digital Content Producer
Antibiotic treatment decreases levels of disease-causing plaques, a hallmark of Alzheimer's disease, according to a new study by neuroscientists...
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Scientific milestone reached in Eisai – UCL Alzheimer’s collaboration
27 June 2016 | By Victoria White, Digital Content Producer
Eisai and UCL have reached the first scientific milestone in their neurodegenerative disease drug discovery and development collaboration...
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Evidence that gut microbes can influence brain inflammation
9 May 2016 | By Victoria White, Digital Content Producer
New research suggests that gut microbes may remotely influence the activity of cells in the brain that are involved in inflammation and neurodegeneration...