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Pancreatic cancer

news

INPP4B exerts its tumour-promoting effects via lysosomes

31 October 2024 | By Drug Target Review

Researchers have uncovered a how INPP4B, alongside PIKfyve and TRPML-1, drives pancreatic cancer metastasis.

news

New network model efficiently identifies cancer driver genes

16 September 2024 | By Drug Target Review

The model enables researchers to expand the number of tumours that they can study, increasing their ability to detect novel interactions.

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Pancreatic cancer suppressed by humanised anti-CKAP4 antibody

29 August 2024 | By Drug Target Review

The humanised antibody, Hv1Lt1, showed promising results in pancreatic cancer mouse models.

news

Ketogenic diet and a new cancer drug starves pancreatic cells

16 August 2024 | By Drug Target Review

The discovery that eFT508 blocks eIF4E and the ketogenic pathway could provide the foundation for personalised therapies.

news

Overcoming chemotherapy resistance in pancreatic cancer

10 July 2024 | By Drug Target Review

Researchers have discovered that pancreatic cancer’s resistance to chemotherapy is related to the physical stiffness of the extracellular matrix.

news

Predicting pancreatic cancer metastasis

2 July 2024 | By Drug Target Review

Molecular, cellular and metabolic analyses of liver biopsies identified markers that may predict subsequent metastasis of pancreatic cancer.

news

Explaining uveal melanoma’s resistance to conventional immunotherapies

17 April 2024 | By Drug Target Review

Researchers have developed a new tool called ‘Uveal Melanoma Immunogenic Score’ to predict which patients will respond to adoptive therapy.

news

Elucidating the mechanism that initiates cancer cachexia

15 April 2024 | By Drug Target Review

The new findings could lead to new therapeutics and a method to diagnose pancreatic cancer earlier, improving its prognosis.

article

Breakthrough for pancreatic cancer treatment

7 March 2024 | By Ellen Capon (Drug Target Review)

Researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.

article

Allosteric control sites in KRAS protein found

5 January 2024 | By Ellen Capon (Drug Target Review)

The first complete control map for any protein has been made for KRAS, and four potential drug targets have been discovered.

article

Combining autotaxin and TGF-β inhibitors in cancer

22 November 2023 | By Ellen Capon (Drug Target Review)

Dr Catherine Pickering, CEO of iOnctura, the clinical stage biopharmaceutical company delivering pioneering cancer treatments to patients with unmet medical needs, is at the forefront of cancer drug discovery. Dr Pickering and her team identify targets that have crucial roles in multiple tumour survival pathways, collaborate with world-renowned scientists and…

news

Pancreatic tumours fooled by glutamine mimic

13 October 2023 | By Drug Target Review

A novel treatment approach using DON molecule starves tumours of essential nutrient, significantly slowing tumour growth.

news

New treatment pathway for deadly pancreatic cancers

25 April 2023 | By Izzy Wood (Drug Target Review)

US scientists have used mouse models of pancreatic cancer to identify genes used by tumour cells to grow uncontrollably.

news

Biomarkers show promise for identifying early risk of pancreatic cancer

21 March 2023 | By Ria Kakkad (Drug Target Review)

The finding is an critical first step towards classifying lesions on the pancreas that are at highest risk of becoming cancerous, enabling their removal before they start to spread.

news

Discovery of CAFs’ origin gives new direction for pancreatic cancer

1 February 2023 | By Izzy Wood (Drug Target Review)

US researchers discovered a type of cell involved it pancreatic cancer and sheds light on the origin of cancer-associated fibroblasts (CAFs).

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Pancreatic cancer