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Stem cell-based vaccine protects mice against pancreatic cancer
Researchers have developed a vaccine using stem cells that protected mice injected with pancreatic cancer cells from developing tumours.
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Pancreatic cancer
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New 3D organoid model of pancreas developed from human stem cells
Researchers have developed the first 3D organoid models of the pancreas that includes both the acinar and ductal structures.
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NAD depletion by IFN sensitises pancreatic cancer to NAMPT inhibition, study shows
High IFN signalling in pancreatic tumours are sensitive to NAMPT inhibitors which block a pathway in NAD synthesis, presenting a drug target.
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ProAgio drug shows success against solid tumours in mice
Studies in mice have shown that the drug ProAgio is effective at treating pancreatic cancer and triple-negative breast cancer.
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Tissue damage and genetic mutations interact to drive pancreatic cancer, finds study
New research shows tissue damage to cells carrying KRAS mutations induces epigenetic changes that promote pancreatic cancer.
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AI advancing drug discovery: the future is multi-cellular studies
Drs Sam Cooper and Michael Briskin of Phenomic AI, discuss how artificial intelligence (AI) is enabling them to target multi-cellular interactions, such as those in the tumour stroma, for drug development.
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Trends in pancreatic cancer literature – findings from Elsevier
In a new report, Elsevier describes how it used text mining to reveal the top trends in pancreatic cancer research – this article outlines the findings.
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A rational approach to discover and precision-engineer new biologic drugs
When it comes to developing antibody drugs, Dr Jerome Boyd-Kirkup and his team are not sticking to the classical playbook. Here, he explains how they use systems biology and immuno-engineering to remove the element of luck from biologic drug discovery and development.
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Cancer-killing virus could improve precision medicine
A new cancer-killing virus called CF33 has shown success in pre-clinical trials, helping the immune system to eradicate tumours.
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Novel imaging technique captures multiple tissues in 3D
A new imaging method called FLASH can provide a visualisation of several tissue types in a 3D format, its developers say.
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Novel antibody-drug candidate to treat pancreatic cancer developed
Scientists have developed a new antibody-drug conjugate (ADC), made from ICAM1, an antibody that targets pancreatic cancer and the cytotoxic drug DM1 (mertansine).
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Novel vaccine protects mice from lung, bowel and pancreatic cancer
By targeting the mutated KRAS gene, researchers have developed an experimental vaccine that protected mice against a range of cancers.
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Study identifies potential therapeutic targets for most lethal pancreatic cancer
The detailed analysis of adenosquamous cancer of the pancreas (ASCP) suggested FGFR and RORC were two promising therapeutic targets.
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Inhibiting sortilin could make pancreatic cancer therapies more effective
A study has shown that inhibiting sortilin, a neuroprotein known to have increased expression in cancers, reduces pancreatic cancer invasiveness in vitro.
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Metastasis-preventing drug target for pancreatic cancer identified
A protein called PPP1R1B has been revealed as a drug target for pancreatic cancer as it stopped the metastasis of tumours in mice.