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The genetic mutation causing the development of psoriatic arthritis
Mutation in two copies of the IKBKB gene leads to abnormal function of regulatory T cells, causing psoriatic arthritis.
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Psoriasis
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New screening technique to accelerate the discovery of cancer-fighting drugs
The novel screening technique can identify molecules that can disable dangerous proteins before they cause diseases by blocking them from interacting with a cell’s DNA.
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Determining the structure of nanobodies using nuclear magnetic resonance spectroscopy
Scientists at the New York University (NYU) Abu Dhabi have used nuclear magnetic resonance (NMR) techniques to determine the structure of a specific nanobody, Nb23. Drug Target Review’s Victoria Rees spoke with lead researcher Professor Gennaro Esposito to find out how their findings could lead to a better understanding of…
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Targeting interferon kappa could control psoriasis inflammation
Scientists found that changing interferon kappa levels altered the severity of psoriasis inflammation and cytokine production in mice.
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Self-assembling nanofibres could prevent damage from inflammation
A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.
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Treating cytokine storms in COVID-19 patients
Enosi Life Science researchers Sir Marc Feldmann, Dr H Michael Shepard and Dr Fiona McCann explain why anti-TNF therapies may be effective in treating COVID-19 associated cytokine storms and other inflammatory conditions.
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Novel siRNA therapy improves psoriasis in mice
Topical delivery of a small interfering RNA (siRNA) using an ionic liquid complex significantly reduced levels of inflammatory cytokines and symptoms of psoriasis.
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Oncology meets immunology – antibody-mediated regulation of the immune response
In this article, Aparajita Dubey discusses the role of antibodies in regulating the immune system and highlights key features that need to be considered for drug development and how this can be applied to cancer therapy.
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Inhibiting VEGFA signalling protects mice against psoriasis
Researchers have found inhibiting vascular endothelial growth factor A (VEGFA) signalling can mediate psoriasis development in the epidermis and could be a potential target for novel therapies.
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Inflammatory regulatory protein identified by researchers
A study has discovered that the PKM2 protein plays a role in regulating immune cells and blocking this could be a potential treatment for inflammatory diseases.
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New imaging tools that trace key breast cancer enzymes may help guide therapies
Series of molecules may provide more reliable relief with fewer side effects...
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Psoriasis treated with compound derived from immune cells
A compound may be effective against other autoimmune diseases, mouse study shows...
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Venomous compounds may lead to better skin treatments
Compounds derived from fire ant venom can reduce skin thickening and inflammation in psoriasis...
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Largest psoriasis meta-analysis to date yields new genetic clues
1-2% of the US population have psoriasis, an immune-mediated disease that causes red, patchy and scaly marks on the skin.
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Anti-inflammatory drugs could treat symptoms of depression
18 October 2016 | By Niamh Louise Marriott, Digital Content Producer
Anti-inflammatory drugs, like those used to treat rheumatoid arthritis and psoriasis could in future be used to treat some cases of depression...