TALEN is a more efficient gene editing tool for tightly packed DNA, finds study
TALEN was shown to be almost five times more efficient than CRISPR-Cas9 at locating and editing genes in heterochromatin.
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TALEN was shown to be almost five times more efficient than CRISPR-Cas9 at locating and editing genes in heterochromatin.
New cell experiments show more effective genetic 'cuts' that could one day become the foundation of more effective gene therapies.
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
New computer model that simulates the way red blood cells become misshapen by sickle cell disease could identity promising drug candidates.
Researchers announce positive pre-clinical results for two sickle cell disease treatment strategies.
A protein identified in the signalling pathway for haemoglobin production has been identified as a possible target to treat sickle cell disease (SCD)...
15 August 2016 | By Niamh Louise Marriott, Digital Content Producer
Foetal haemoglobin lacks beta sub-units and has gamma sub-units instead. Thus, beta-thalassemia or SCD–associated mutations, which impair the production or function of the beta sub-unit, do not cause problems with foetal haemoglobin, which can transport oxygen effectively in adults...
16 July 2015 | By Victoria White
Researchers have developed a user-friendly resource to accompany the powerful CRISPR/Cas9 tool, which has been widely adopted to make precise changes in DNA...