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Skin cancer

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Novel radioactive drug targets aggressive metastatic melanoma

25 March 2025 | By Drug Target Review

Scientists in Japan have developed a new radioactive drug that emits alpha particles, showing promise for targeting metastatic melanoma - an aggressive skin cancer resistant to many conventional treatments.

article

Transforming cancer treatment for greatest impact

15 January 2024 | By Dr Lev Becker (Onchilles Pharma)

In this Q&A, Dr Lev Becker, Associate Professor, University of Chicago and Cofounder of Onchilles Pharma, reveals how his company is directing research into neutrophil biology to the advantage of cancer patients that need it most.

news

Intratumoural bacteria drives radiation therapy resistance

23 October 2023 | By Drug Target Review

Lactate producing bacteria is responsible for rewiring metabolic signalling pathways, causing resistance to radiation therapy.

news

Accelerating the immune system could eliminate ageing cells

11 April 2023 | By Taylor Mixides (Drug Target Review)

Boosting the body’s anti-viral immune response could restore tissue balance and eliminate ageing cells that contribute to age-related diseases.

3D rendering of a NK Cell (Natural Killer Cell) destroying a cancer cell

news

Stopping immune cell leakage from tumours could improve skin cancer treatment

3 March 2023 | By Ria Kakkad (Drug Target Review), Tony Portelli (Drug Target Review)

Results show the number of specialised immune cells available for fighting skin cancer doubled when a new treatment blocked their escape from melanoma tumours.

news

Researchers investigate gene network to identify “cancer driver genes”

14 December 2021 | By Anna Begley (Drug Target Review)

The new study looked at the network of gene-gene interactions associated with cancer onset and progression to identify therapeutic targets.

news

Therapeutic target for aggressive cancers discovered through CRISPR

5 August 2021 | By Anna Begley (Drug Target Review)

The RNA-modifying protein METTL1 could be targeted to treat some types of aggressive cancers, including brain, blood and kidney.

3D illustration of a tumour cell under cross hares

article

NOX5: a novel target for sensitising melanoma to therapies

19 February 2021 | By Hannah Balfour (Drug Target Review)

Vito Quaranta, professor of biochemistry and pharmacology, discusses how cancerous cells adopting novel mechanisms of energy production could be sensitised to existing therapies with a focus on melanoma.

artist impression of a red T cell attacking a blue cancer cell

news

Providing cancer immunotherapies with a boost could reduce cancer recurrence

16 July 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal drugs inhibiting Neuropilin-1 (NRP1), a protein expressed on T cells, could improve the efficacy of immunotherapies.

news

T-cell regulator SLAMF6 may be hindering immunotherapy success

5 March 2020 | By Mandy Parrett (Drug Target Review)

A new study conducted in Israel suggests that T cells’ ability to destroy skin cancer increases in the absence of T-cell regulators called SLAMF6.

news

Infrared light used to improve photodynamic therapy in model tumours

27 February 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a compound that can be activated with infrared light to kill cancer cells in model tumours, advancing the possibilities of photodynamic therapy.

3D rendering of an artists impression of cancer cells

news

Research into CDK8 oncogene could improve design of future therapeutics

29 January 2020 | By Hannah Balfour (Drug Target Review)

A study has shown that type II kinase inhibitors targeting CDK8 alone are ineffective because mutations leave them inactive, suggesting future therapies should target CDK8 in complex.

news

DIRC3 tumour suppressor could be a new target for melanoma therapies

16 January 2020 | By Hannah Balfour (Drug Target Review)

A study has shown that long non-coding RNA called DIRC3 can block melanoma growth and could be used to identify new targets for skin cancer therapies.

news

New route identified for tackling drug resistance in skin cancer cells

14 January 2020 | By Rachael Harper (Drug Target Review)

A new therapeutic route for combatting treatment-resistant cancer has been identified with the discovery that melanoma cells fight anti-cancer drugs by changing their internal skeleton.

news

Fungi library could aid in the search for medical drugs

27 November 2019 | By Rachael Harper (Drug Target Review)

A library of products derived from more than 10,000 fungi has been established which could lead to the discovery of new drugs.

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Skin cancer